Significantly increased anti‐tumor activity of carcinoembryonic antigen‐specific chimeric antigen receptor T cells in combination with recombinant human IL‐12

Significantly increased anti‐tumor activity of carcinoembryonic antigen‐specific chimeric antigen receptor T cells in combination with recombinant human IL‐12

Abstract Background aims Chimeric antigen receptor T cells (CAR‐T cells) have been successfully used in treatments of hematological tumors, however, their anti‐tumor activity in solid tumor treatments was limited. As IL‐12 increases T‐cell immune functions, we designed carcinoembryonic antigen (CEA)...

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Bibliographic Details
Main Authors: Xiaowei Chi, Peiwei Yang, Erhao Zhang, Jieyi Gu, Hui Xu, Mengwei Li, Xinmei Gao, Xin Li, Yinan Zhang, Hanmei Xu, Jialiang Hu
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Cancer Medicine
Subjects:
carcinoembryonic antigen
chimeric antigen receptor T cell
colorectal cancer
gastric cancer
IL‐12
pancreatic cancer
Online Access:https://doi.org/10.1002/cam4.2361

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