Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches
Epithelial-mesenchymal transition (EMT) constitutes one of the hallmarks of carcinogenesis consisting in the re-differentiation of the epithelial cells into mesenchymal ones changing the cellular phenotype into a malignant one. EMT has been shown to play a role in the malignant transformation and wh...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/1/277 |
| _version_ | 1797543189450588160 |
|---|---|
| author | Joanna Kozak Alicja Forma Marcin Czeczelewski Paweł Kozyra Elżbieta Sitarz Elżbieta Radzikowska-Büchner Monika Sitarz Jacek Baj |
| author_facet | Joanna Kozak Alicja Forma Marcin Czeczelewski Paweł Kozyra Elżbieta Sitarz Elżbieta Radzikowska-Büchner Monika Sitarz Jacek Baj |
| author_sort | Joanna Kozak |
| collection | DOAJ |
| description | Epithelial-mesenchymal transition (EMT) constitutes one of the hallmarks of carcinogenesis consisting in the re-differentiation of the epithelial cells into mesenchymal ones changing the cellular phenotype into a malignant one. EMT has been shown to play a role in the malignant transformation and while occurring in the tumor microenvironment, it significantly affects the aggressiveness of gastric cancer, among others. Importantly, after EMT occurs, gastric cancer patients are more susceptible to the induction of resistance to various therapeutic agents, worsening the clinical outcome of patients. Therefore, there is an urgent need to search for the newest pharmacological agents targeting EMT to prevent further progression of gastric carcinogenesis and potential metastases. Therapies targeted at EMT might be combined with other currently available treatment modalities, which seems to be an effective strategy to treat gastric cancer patients. In this review, we have summarized recent advances in gastric cancer treatment in terms of targeting EMT specifically, such as the administration of polyphenols, resveratrol, tangeretin, luteolin, genistein, proton pump inhibitors, terpenes, other plant extracts, or inorganic compounds. |
| first_indexed | 2024-03-10T13:41:04Z |
| format | Article |
| id | doaj.art-d9a80f8d711f4ff481093b9c95c39386 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:41:04Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d9a80f8d711f4ff481093b9c95c393862023-11-21T03:02:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122127710.3390/ijms22010277Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological ApproachesJoanna Kozak0Alicja Forma1Marcin Czeczelewski2Paweł Kozyra3Elżbieta Sitarz4Elżbieta Radzikowska-Büchner5Monika Sitarz6Jacek Baj7Department of Human Anatomy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, PolandStudent Research Group, Independent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, PL-20093 Lublin, Poland1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, Gluska Street 1, 20-439 Lublin, PolandDepartment of Plastic Surgery, Central Clinical Hospital of the Ministry of the Interior in Warsaw, 01-211 Warsaw, PolandDepartment of Conservative Dentistry with Endodontics, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Human Anatomy, Medical University of Lublin, 20-090 Lublin, PolandEpithelial-mesenchymal transition (EMT) constitutes one of the hallmarks of carcinogenesis consisting in the re-differentiation of the epithelial cells into mesenchymal ones changing the cellular phenotype into a malignant one. EMT has been shown to play a role in the malignant transformation and while occurring in the tumor microenvironment, it significantly affects the aggressiveness of gastric cancer, among others. Importantly, after EMT occurs, gastric cancer patients are more susceptible to the induction of resistance to various therapeutic agents, worsening the clinical outcome of patients. Therefore, there is an urgent need to search for the newest pharmacological agents targeting EMT to prevent further progression of gastric carcinogenesis and potential metastases. Therapies targeted at EMT might be combined with other currently available treatment modalities, which seems to be an effective strategy to treat gastric cancer patients. In this review, we have summarized recent advances in gastric cancer treatment in terms of targeting EMT specifically, such as the administration of polyphenols, resveratrol, tangeretin, luteolin, genistein, proton pump inhibitors, terpenes, other plant extracts, or inorganic compounds.https://www.mdpi.com/1422-0067/22/1/277gastric cancerepithelial-mesenchymal transitionEMTpharmacotherapy |
| spellingShingle | Joanna Kozak Alicja Forma Marcin Czeczelewski Paweł Kozyra Elżbieta Sitarz Elżbieta Radzikowska-Büchner Monika Sitarz Jacek Baj Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches International Journal of Molecular Sciences gastric cancer epithelial-mesenchymal transition EMT pharmacotherapy |
| title | Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches |
| title_full | Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches |
| title_fullStr | Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches |
| title_full_unstemmed | Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches |
| title_short | Inhibition or Reversal of the Epithelial-Mesenchymal Transition in Gastric Cancer: Pharmacological Approaches |
| title_sort | inhibition or reversal of the epithelial mesenchymal transition in gastric cancer pharmacological approaches |
| topic | gastric cancer epithelial-mesenchymal transition EMT pharmacotherapy |
| url | https://www.mdpi.com/1422-0067/22/1/277 |
| work_keys_str_mv | AT joannakozak inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches AT alicjaforma inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches AT marcinczeczelewski inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches AT pawełkozyra inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches AT elzbietasitarz inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches AT elzbietaradzikowskabuchner inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches AT monikasitarz inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches AT jacekbaj inhibitionorreversaloftheepithelialmesenchymaltransitioningastriccancerpharmacologicalapproaches |