69766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysis
ABSTRACT IMPACT: Many who suffer from end-stage organ disease do not qualify for solid organ transplantation because of obesity; however, bariatric surgery offers the potential to render select patients transplant-eligible, and in some cases, may lead to weight loss that is sufficient to reverse end...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-03-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866121005872/type/journal_article |
| _version_ | 1811155318013427712 |
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| author | Babak Orandi Joshua Purvis Robert Cannon Blair Smith Cora Lewis Norah Terrault Jayme Locke |
| author_facet | Babak Orandi Joshua Purvis Robert Cannon Blair Smith Cora Lewis Norah Terrault Jayme Locke |
| author_sort | Babak Orandi |
| collection | DOAJ |
| description | ABSTRACT IMPACT: Many who suffer from end-stage organ disease do not qualify for solid organ transplantation because of obesity; however, bariatric surgery offers the potential to render select patients transplant-eligible, and in some cases, may lead to weight loss that is sufficient to reverse end-stage organ disease. OBJECTIVES/GOALS: As obesity prevalence grows, more end-stage organ disease patients will be precluded from transplant. Numerous reports suggest bariatric surgery in end-stage organ disease may help patients achieve weight loss sufficient for transplant listing, though the published data are limited. METHODS/STUDY POPULATION: We performed a systematic review/meta-analysis of studies of bariatric surgery to achieve solid organ transplant listing. RESULTS/ANTICIPATED RESULTS: Among 82 heart failure patients, 40.2% lost sufficient weight for listing, 29.3% were transplanted, and 8.5% had sufficient improvement with weight loss they no longer required transplantation. Among 28 end-stage lung disease patients, 28.6% lost sufficient weight for listing, 7.1% were transplanted, and 14.3% had sufficient improvement following weight loss they no longer required transplant. Among 41 cirrhosis patients, 58.5% lost sufficient weight for listing, 41.5% were transplanted, and 21.9% had sufficient improvement following weight loss they no longer required transplant. Among 288 end-stage/chronic kidney disease patients, 50.3% lost sufficient weight for listing and 29.5% were transplanted. DISCUSSION/SIGNIFICANCE OF FINDINGS: Small sample size and publication bias are limitations; however, bariatric surgery may benefit select end-stage organ disease patients with obesity that precludes transplant candidacy. |
| first_indexed | 2024-04-10T04:32:13Z |
| format | Article |
| id | doaj.art-d9a8d3a7f81e4e138f3981b421555899 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:32:13Z |
| publishDate | 2021-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-d9a8d3a7f81e4e138f3981b4215558992023-03-10T07:52:04ZengCambridge University PressJournal of Clinical and Translational Science2059-86612021-03-015717210.1017/cts.2021.58769766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysisBabak Orandi0Joshua Purvis1Robert Cannon2Blair Smith3Cora Lewis4Norah Terrault5Jayme Locke6UABUABUABUABUABUSCUABABSTRACT IMPACT: Many who suffer from end-stage organ disease do not qualify for solid organ transplantation because of obesity; however, bariatric surgery offers the potential to render select patients transplant-eligible, and in some cases, may lead to weight loss that is sufficient to reverse end-stage organ disease. OBJECTIVES/GOALS: As obesity prevalence grows, more end-stage organ disease patients will be precluded from transplant. Numerous reports suggest bariatric surgery in end-stage organ disease may help patients achieve weight loss sufficient for transplant listing, though the published data are limited. METHODS/STUDY POPULATION: We performed a systematic review/meta-analysis of studies of bariatric surgery to achieve solid organ transplant listing. RESULTS/ANTICIPATED RESULTS: Among 82 heart failure patients, 40.2% lost sufficient weight for listing, 29.3% were transplanted, and 8.5% had sufficient improvement with weight loss they no longer required transplantation. Among 28 end-stage lung disease patients, 28.6% lost sufficient weight for listing, 7.1% were transplanted, and 14.3% had sufficient improvement following weight loss they no longer required transplant. Among 41 cirrhosis patients, 58.5% lost sufficient weight for listing, 41.5% were transplanted, and 21.9% had sufficient improvement following weight loss they no longer required transplant. Among 288 end-stage/chronic kidney disease patients, 50.3% lost sufficient weight for listing and 29.5% were transplanted. DISCUSSION/SIGNIFICANCE OF FINDINGS: Small sample size and publication bias are limitations; however, bariatric surgery may benefit select end-stage organ disease patients with obesity that precludes transplant candidacy.https://www.cambridge.org/core/product/identifier/S2059866121005872/type/journal_article |
| spellingShingle | Babak Orandi Joshua Purvis Robert Cannon Blair Smith Cora Lewis Norah Terrault Jayme Locke 69766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysis Journal of Clinical and Translational Science |
| title | 69766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysis |
| title_full | 69766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysis |
| title_fullStr | 69766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysis |
| title_full_unstemmed | 69766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysis |
| title_short | 69766 Bariatric surgery to achieve transplant in end-stage organ diseasepatients: A systematic review and meta-analysis |
| title_sort | 69766 bariatric surgery to achieve transplant in end stage organ diseasepatients a systematic review and meta analysis |
| url | https://www.cambridge.org/core/product/identifier/S2059866121005872/type/journal_article |
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