Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway
Skin is susceptible to premature aging in response to ultraviolet (UV) radiation-induced oxidative stress, which can ultimately result in aberrant aging or age-related disorders. Accordingly, strategies that can be adopted to mitigate oxidative stress may contribute to protecting skin from induced a...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222301908X |
| _version_ | 1797324432533880832 |
|---|---|
| author | Tao Liu Shan Zhu Yi Yang Wenxiao Qin Zijing Wang Zhiyue Zhao Tao Liu Xiang Wang Tian Duan Yang Liu Yan Liu Qingmei Xia Han Zhang Nan Li |
| author_facet | Tao Liu Shan Zhu Yi Yang Wenxiao Qin Zijing Wang Zhiyue Zhao Tao Liu Xiang Wang Tian Duan Yang Liu Yan Liu Qingmei Xia Han Zhang Nan Li |
| author_sort | Tao Liu |
| collection | DOAJ |
| description | Skin is susceptible to premature aging in response to ultraviolet (UV) radiation-induced oxidative stress, which can ultimately result in aberrant aging or age-related disorders. Accordingly, strategies that can be adopted to mitigate oxidative stress may contribute to protecting skin from induced aging-related damage, thereby offering promising approaches for the treatment of skin diseases and disorders. In this regard, oroxylin A (OA), a natural flavonoid isolated from certain plants used in traditional Chinese medicine, is considered to have notable antioxidant, anti-inflammatory, and anti-apoptotic properties, and is often used to treat certain inflammatory diseases. To date, however, there has been comparatively little research on the effects of OA with respect skin aging. In this study, we utilized UV radiation-induced mouse and cellular models of aging to assess the efficacy of OA in protecting against skin aging. Subsequently, to elucidate the potential mechanisms underlying the protective effect of OA on skin aging, we performed molecular docking analysis to investigate the involvement of the anti-aging gene Sirt1, which was further confirmed on the basis of Sirt1 gene silencing. We accordingly demonstrated that by promoting an increase in the expression of Sirt1, OA can contribute to suppressing UV-induced skin photo-aging in cells/mice by reducing oxidative stress. Furthermore, we established that by activating Sirt1, OA can also promote the dissociation of Nrf2 from Keap1 and its subsequent nuclear translocation. Collectively, our findings in this study reveal OA to be an effective natural compound that can be administered to delay the aging of skin triggered by UV, both in vivo and in vitro, by binding to Sirt1 to promote the deacetylation and nuclear translocation of Nrf2, thereby contributing to a reduction in oxidative stress. These findings may this provide a therapeutic target for the prevention of skin aging or aging-induced skin diseases. |
| first_indexed | 2024-03-08T05:56:03Z |
| format | Article |
| id | doaj.art-d9a9bf62ca7b40398498178f8fa75b12 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T05:56:03Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-d9a9bf62ca7b40398498178f8fa75b122024-02-05T04:31:04ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-02-01171116110Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathwayTao Liu0Shan Zhu1Yi Yang2Wenxiao Qin3Zijing Wang4Zhiyue Zhao5Tao Liu6Xiang Wang7Tian Duan8Yang Liu9Yan Liu10Qingmei Xia11Han Zhang12Nan Li13Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR ChinaChinese medical college,Tianjin University of Traditional Chinese Medicine, Tianjin, PR ChinaTianjin Polytechnic University, Tianjin, PR ChinaChinese medical college,Tianjin University of Traditional Chinese Medicine, Tianjin, PR ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR China; Corresponding authors at: Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China.Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR China; Engineering research center of Modern chinese Medicine Discovery and Preparation Technique, Ministry of education, Tianjin University of Traditional chinese Medicine, Tianjin, PR China; Corresponding authors at: Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China.Skin is susceptible to premature aging in response to ultraviolet (UV) radiation-induced oxidative stress, which can ultimately result in aberrant aging or age-related disorders. Accordingly, strategies that can be adopted to mitigate oxidative stress may contribute to protecting skin from induced aging-related damage, thereby offering promising approaches for the treatment of skin diseases and disorders. In this regard, oroxylin A (OA), a natural flavonoid isolated from certain plants used in traditional Chinese medicine, is considered to have notable antioxidant, anti-inflammatory, and anti-apoptotic properties, and is often used to treat certain inflammatory diseases. To date, however, there has been comparatively little research on the effects of OA with respect skin aging. In this study, we utilized UV radiation-induced mouse and cellular models of aging to assess the efficacy of OA in protecting against skin aging. Subsequently, to elucidate the potential mechanisms underlying the protective effect of OA on skin aging, we performed molecular docking analysis to investigate the involvement of the anti-aging gene Sirt1, which was further confirmed on the basis of Sirt1 gene silencing. We accordingly demonstrated that by promoting an increase in the expression of Sirt1, OA can contribute to suppressing UV-induced skin photo-aging in cells/mice by reducing oxidative stress. Furthermore, we established that by activating Sirt1, OA can also promote the dissociation of Nrf2 from Keap1 and its subsequent nuclear translocation. Collectively, our findings in this study reveal OA to be an effective natural compound that can be administered to delay the aging of skin triggered by UV, both in vivo and in vitro, by binding to Sirt1 to promote the deacetylation and nuclear translocation of Nrf2, thereby contributing to a reduction in oxidative stress. These findings may this provide a therapeutic target for the prevention of skin aging or aging-induced skin diseases.http://www.sciencedirect.com/science/article/pii/S075333222301908XOroxylin ASirt1Nrf2AcetylationOxidative stressNatural compound |
| spellingShingle | Tao Liu Shan Zhu Yi Yang Wenxiao Qin Zijing Wang Zhiyue Zhao Tao Liu Xiang Wang Tian Duan Yang Liu Yan Liu Qingmei Xia Han Zhang Nan Li Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway Biomedicine & Pharmacotherapy Oroxylin A Sirt1 Nrf2 Acetylation Oxidative stress Natural compound |
| title | Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway |
| title_full | Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway |
| title_fullStr | Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway |
| title_full_unstemmed | Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway |
| title_short | Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway |
| title_sort | oroxylin a ameliorates ultraviolet radiation induced premature skin aging by regulating oxidative stress via the sirt1 pathway |
| topic | Oroxylin A Sirt1 Nrf2 Acetylation Oxidative stress Natural compound |
| url | http://www.sciencedirect.com/science/article/pii/S075333222301908X |
| work_keys_str_mv | AT taoliu oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT shanzhu oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT yiyang oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT wenxiaoqin oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT zijingwang oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT zhiyuezhao oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT taoliu oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT xiangwang oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT tianduan oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT yangliu oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT yanliu oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT qingmeixia oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT hanzhang oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway AT nanli oroxylinaamelioratesultravioletradiationinducedprematureskinagingbyregulatingoxidativestressviathesirt1pathway |