It’s MORe exciting than mu: Crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system

It’s MORe exciting than mu: Crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system

Opioids selective for the G-protein coupled mu opioid receptor (MOR) produce potent analgesia and euphoria. Heroin, a synthetic opioid, is considered one of the most addictive substances, and the recent exponential rise in opioid addiction and overdose deaths has made treatment development a nation...

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Bibliographic Details
Main Authors: Elena H Chartoff, Hilary Smith Connery
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Pharmacology
Subjects:
Heroin
Morphine
Nucleus Accumbens
NMDA
plasticity
AMPA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00116/full

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