Association of ficolin-3 with severity and outcome of chronic heart failure.
BACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MB...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3626638?pdf=render |
| _version_ | 1811264668585426944 |
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| author | Zoltán Prohászka Lea Munthe-Fog Thor Ueland Timea Gombos Arne Yndestad Zsolt Förhécz Mikkel-Ole Skjoedt Zoltan Pozsonyi Alice Gustavsen Lívia Jánoskuti István Karádi Lars Gullestad Christen P Dahl Erik T Askevold George Füst Pål Aukrust Tom E Mollnes Peter Garred |
| author_facet | Zoltán Prohászka Lea Munthe-Fog Thor Ueland Timea Gombos Arne Yndestad Zsolt Förhécz Mikkel-Ole Skjoedt Zoltan Pozsonyi Alice Gustavsen Lívia Jánoskuti István Karádi Lars Gullestad Christen P Dahl Erik T Askevold George Füst Pål Aukrust Tom E Mollnes Peter Garred |
| author_sort | Zoltán Prohászka |
| collection | DOAJ |
| description | BACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure. METHODS AND RESULTS: MBL, ficolin-2 and ficolin-3 plasma concentrations were determined in two consecutive cohorts comprising 190 patients from Hungary and 183 patients from Norway as well as controls. Disease severity and clinical parameters were determined at baseline, and all-cause mortality was registered after 5-years follow-up. In univariate analysis a low level of ficolin-3, but not that of MBL or ficolin-2, was significantly associated with advanced heart failure (New York Heart Association Class IV, p<0.001 for both cohorts) and showed inverse correlation with B- type natriuretic peptide (BNP) levels (r = -0.609, p<0.001 and r = -0.467, p<0.001, respectively). In multivariable Cox regression analysis, adjusted for age, gender and BNP, decreased plasma ficolin-3 was a significant predictor of mortality (HR 1.368, 95% CI 1.052-6.210; and HR 1.426, 95% CI 1.013-2.008, respectively). Low ficolin-3 levels were associated with increased complement activation product C3a and correspondingly decreased concentrations of complement factor C3. CONCLUSIONS: This study provides evidence for an association of low ficolin-3 levels with advanced heart failure. Concordant results from two cohorts show that low levels of ficolin-3 are associated with advanced heart failure and outcome. The decrease of ficolin-3 was associated with increased complement activation. |
| first_indexed | 2024-04-12T20:08:31Z |
| format | Article |
| id | doaj.art-d9aa4c2e045c444997483c0f62bd0674 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T20:08:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d9aa4c2e045c444997483c0f62bd06742022-12-22T03:18:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6097610.1371/journal.pone.0060976Association of ficolin-3 with severity and outcome of chronic heart failure.Zoltán ProhászkaLea Munthe-FogThor UelandTimea GombosArne YndestadZsolt FörhéczMikkel-Ole SkjoedtZoltan PozsonyiAlice GustavsenLívia JánoskutiIstván KarádiLars GullestadChristen P DahlErik T AskevoldGeorge FüstPål AukrustTom E MollnesPeter GarredBACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure. METHODS AND RESULTS: MBL, ficolin-2 and ficolin-3 plasma concentrations were determined in two consecutive cohorts comprising 190 patients from Hungary and 183 patients from Norway as well as controls. Disease severity and clinical parameters were determined at baseline, and all-cause mortality was registered after 5-years follow-up. In univariate analysis a low level of ficolin-3, but not that of MBL or ficolin-2, was significantly associated with advanced heart failure (New York Heart Association Class IV, p<0.001 for both cohorts) and showed inverse correlation with B- type natriuretic peptide (BNP) levels (r = -0.609, p<0.001 and r = -0.467, p<0.001, respectively). In multivariable Cox regression analysis, adjusted for age, gender and BNP, decreased plasma ficolin-3 was a significant predictor of mortality (HR 1.368, 95% CI 1.052-6.210; and HR 1.426, 95% CI 1.013-2.008, respectively). Low ficolin-3 levels were associated with increased complement activation product C3a and correspondingly decreased concentrations of complement factor C3. CONCLUSIONS: This study provides evidence for an association of low ficolin-3 levels with advanced heart failure. Concordant results from two cohorts show that low levels of ficolin-3 are associated with advanced heart failure and outcome. The decrease of ficolin-3 was associated with increased complement activation.http://europepmc.org/articles/PMC3626638?pdf=render |
| spellingShingle | Zoltán Prohászka Lea Munthe-Fog Thor Ueland Timea Gombos Arne Yndestad Zsolt Förhécz Mikkel-Ole Skjoedt Zoltan Pozsonyi Alice Gustavsen Lívia Jánoskuti István Karádi Lars Gullestad Christen P Dahl Erik T Askevold George Füst Pål Aukrust Tom E Mollnes Peter Garred Association of ficolin-3 with severity and outcome of chronic heart failure. PLoS ONE |
| title | Association of ficolin-3 with severity and outcome of chronic heart failure. |
| title_full | Association of ficolin-3 with severity and outcome of chronic heart failure. |
| title_fullStr | Association of ficolin-3 with severity and outcome of chronic heart failure. |
| title_full_unstemmed | Association of ficolin-3 with severity and outcome of chronic heart failure. |
| title_short | Association of ficolin-3 with severity and outcome of chronic heart failure. |
| title_sort | association of ficolin 3 with severity and outcome of chronic heart failure |
| url | http://europepmc.org/articles/PMC3626638?pdf=render |
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