Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies
Our dream of defeating the processes of aging has occupied the curious and has challenged scientists globally for hundreds of years. The history is long, and sadly, the solution is still elusive. Our endeavors to reverse the magnitude of damaging cellular and molecular alterations resulted in only a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1343 |
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| author | Klaudia Maar Roland Hetenyi Szabolcs Maar Gabor Faskerti Daniel Hanna Balint Lippai Aniko Takatsy Ildiko Bock-Marquette |
| author_facet | Klaudia Maar Roland Hetenyi Szabolcs Maar Gabor Faskerti Daniel Hanna Balint Lippai Aniko Takatsy Ildiko Bock-Marquette |
| author_sort | Klaudia Maar |
| collection | DOAJ |
| description | Our dream of defeating the processes of aging has occupied the curious and has challenged scientists globally for hundreds of years. The history is long, and sadly, the solution is still elusive. Our endeavors to reverse the magnitude of damaging cellular and molecular alterations resulted in only a few, yet significant advancements. Furthermore, as our lifespan increases, physicians are facing more mind-bending questions in their routine practice than ever before. Although the ultimate goal is to successfully treat the body as a whole, steps towards regenerating individual organs are even considered significant. As our initial approach to enhance the endogenous restorative capacity by delivering exogenous progenitor cells appears limited, we propose, utilizing small molecules critical during embryonic development may prove to be a powerful tool to increase regeneration and to reverse the processes associated with aging. In this review, we introduce Thymosin beta-4, a 43aa secreted peptide fulfilling our hopes and capable of numerous regenerative achievements via systemic administration in the heart. Observing the broad capacity of this small, secreted peptide, we believe it is not the only molecule which nature conceals to our benefit. Hence, the discovery and postnatal administration of developmentally relevant agents along with other approaches may result in reversing the aging process. |
| first_indexed | 2024-03-10T10:56:02Z |
| format | Article |
| id | doaj.art-d9ab97a9b4314d7f8a9b5502913c88f9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:56:02Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d9ab97a9b4314d7f8a9b5502913c88f92023-11-21T21:53:47ZengMDPI AGCells2073-44092021-05-01106134310.3390/cells10061343Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative TherapiesKlaudia Maar0Roland Hetenyi1Szabolcs Maar2Gabor Faskerti3Daniel Hanna4Balint Lippai5Aniko Takatsy6Ildiko Bock-Marquette7Department of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti Street 12., H-7624 Pecs, HungaryDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti Street 12., H-7624 Pecs, HungaryDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti Street 12., H-7624 Pecs, HungaryDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti Street 12., H-7624 Pecs, HungaryDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti Street 12., H-7624 Pecs, HungarySzentagothai Research Centre, Research Group of Regenerative Science, Sport and Medicine, University of Pecs, Ifjusag Street 20. C301, H-7624 Pecs, HungaryDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti Street 12., H-7624 Pecs, HungaryDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti Street 12., H-7624 Pecs, HungaryOur dream of defeating the processes of aging has occupied the curious and has challenged scientists globally for hundreds of years. The history is long, and sadly, the solution is still elusive. Our endeavors to reverse the magnitude of damaging cellular and molecular alterations resulted in only a few, yet significant advancements. Furthermore, as our lifespan increases, physicians are facing more mind-bending questions in their routine practice than ever before. Although the ultimate goal is to successfully treat the body as a whole, steps towards regenerating individual organs are even considered significant. As our initial approach to enhance the endogenous restorative capacity by delivering exogenous progenitor cells appears limited, we propose, utilizing small molecules critical during embryonic development may prove to be a powerful tool to increase regeneration and to reverse the processes associated with aging. In this review, we introduce Thymosin beta-4, a 43aa secreted peptide fulfilling our hopes and capable of numerous regenerative achievements via systemic administration in the heart. Observing the broad capacity of this small, secreted peptide, we believe it is not the only molecule which nature conceals to our benefit. Hence, the discovery and postnatal administration of developmentally relevant agents along with other approaches may result in reversing the aging process.https://www.mdpi.com/2073-4409/10/6/1343agingheart regenerationembryonic developmentthymosin beta-4 |
| spellingShingle | Klaudia Maar Roland Hetenyi Szabolcs Maar Gabor Faskerti Daniel Hanna Balint Lippai Aniko Takatsy Ildiko Bock-Marquette Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies Cells aging heart regeneration embryonic development thymosin beta-4 |
| title | Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies |
| title_full | Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies |
| title_fullStr | Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies |
| title_full_unstemmed | Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies |
| title_short | Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies |
| title_sort | utilizing developmentally essential secreted peptides such as thymosin beta 4 to remind the adult organs of their embryonic state new directions in anti aging regenerative therapies |
| topic | aging heart regeneration embryonic development thymosin beta-4 |
| url | https://www.mdpi.com/2073-4409/10/6/1343 |
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