Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study.
Single nucleotide polymorphisms (SNPs) in genes encoding the components involved in the hypothalamic pathway may influence weight gain and dietary factors may modify their effects.We conducted a case-cohort study to investigate the associations of SNPs in candidate genes with weight change during an...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-02-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3044761?pdf=render |
| _version_ | 1811221434126565376 |
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| author | Huaidong Du Karani S Vimaleswaran Lars Angquist Rikke D Hansen Daphne L van der A Claus Holst Anne Tjønneland Kim Overvad Marianne Uhre Jakobsen Heiner Boeing Karina Meidtner Domenico Palli Giovanna Masala Nabila Bouatia-Naji Wim H M Saris Edith J M Feskens Nicolas J Wareham Thorkild I A Sørensen Ruth J F Loos |
| author_facet | Huaidong Du Karani S Vimaleswaran Lars Angquist Rikke D Hansen Daphne L van der A Claus Holst Anne Tjønneland Kim Overvad Marianne Uhre Jakobsen Heiner Boeing Karina Meidtner Domenico Palli Giovanna Masala Nabila Bouatia-Naji Wim H M Saris Edith J M Feskens Nicolas J Wareham Thorkild I A Sørensen Ruth J F Loos |
| author_sort | Huaidong Du |
| collection | DOAJ |
| description | Single nucleotide polymorphisms (SNPs) in genes encoding the components involved in the hypothalamic pathway may influence weight gain and dietary factors may modify their effects.We conducted a case-cohort study to investigate the associations of SNPs in candidate genes with weight change during an average of 6.8 years of follow-up and to examine the potential effect modification by glycemic index (GI) and protein intake.Participants, aged 20-60 years at baseline, came from five European countries. Cases ('weight gainers') were selected from the total eligible cohort (n = 50,293) as those with the greatest unexplained annual weight gain (n = 5,584). A random subcohort (n = 6,566) was drawn with the intention to obtain an equal number of cases and noncases (n = 5,507). We genotyped 134 SNPs that captured all common genetic variation across the 15 candidate genes; 123 met the quality control criteria. Each SNP was tested for association with the risk of being a 'weight gainer' (logistic regression models) in the case-noncase data and with weight gain (linear regression models) in the random subcohort data. After accounting for multiple testing, none of the SNPs was significantly associated with weight change. Furthermore, we observed no significant effect modification by dietary factors, except for SNP rs7180849 in the neuromedin β gene (NMB). Carriers of the minor allele had a more pronounced weight gain at a higher GI (P = 2 x 10⁻⁷).We found no evidence of association between SNPs in the studied hypothalamic genes with weight change. The interaction between GI and NMB SNP rs7180849 needs further confirmation. |
| first_indexed | 2024-04-12T07:59:16Z |
| format | Article |
| id | doaj.art-d9abacbd1df34a26a29a101e4647dbaf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T07:59:16Z |
| publishDate | 2011-02-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-d9abacbd1df34a26a29a101e4647dbaf2022-12-22T03:41:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-02-0162e1743610.1371/journal.pone.0017436Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study.Huaidong DuKarani S VimaleswaranLars AngquistRikke D HansenDaphne L van der AClaus HolstAnne TjønnelandKim OvervadMarianne Uhre JakobsenHeiner BoeingKarina MeidtnerDomenico PalliGiovanna MasalaNabila Bouatia-NajiWim H M SarisEdith J M FeskensNicolas J WarehamThorkild I A SørensenRuth J F LoosSingle nucleotide polymorphisms (SNPs) in genes encoding the components involved in the hypothalamic pathway may influence weight gain and dietary factors may modify their effects.We conducted a case-cohort study to investigate the associations of SNPs in candidate genes with weight change during an average of 6.8 years of follow-up and to examine the potential effect modification by glycemic index (GI) and protein intake.Participants, aged 20-60 years at baseline, came from five European countries. Cases ('weight gainers') were selected from the total eligible cohort (n = 50,293) as those with the greatest unexplained annual weight gain (n = 5,584). A random subcohort (n = 6,566) was drawn with the intention to obtain an equal number of cases and noncases (n = 5,507). We genotyped 134 SNPs that captured all common genetic variation across the 15 candidate genes; 123 met the quality control criteria. Each SNP was tested for association with the risk of being a 'weight gainer' (logistic regression models) in the case-noncase data and with weight gain (linear regression models) in the random subcohort data. After accounting for multiple testing, none of the SNPs was significantly associated with weight change. Furthermore, we observed no significant effect modification by dietary factors, except for SNP rs7180849 in the neuromedin β gene (NMB). Carriers of the minor allele had a more pronounced weight gain at a higher GI (P = 2 x 10⁻⁷).We found no evidence of association between SNPs in the studied hypothalamic genes with weight change. The interaction between GI and NMB SNP rs7180849 needs further confirmation.http://europepmc.org/articles/PMC3044761?pdf=render |
| spellingShingle | Huaidong Du Karani S Vimaleswaran Lars Angquist Rikke D Hansen Daphne L van der A Claus Holst Anne Tjønneland Kim Overvad Marianne Uhre Jakobsen Heiner Boeing Karina Meidtner Domenico Palli Giovanna Masala Nabila Bouatia-Naji Wim H M Saris Edith J M Feskens Nicolas J Wareham Thorkild I A Sørensen Ruth J F Loos Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. PLoS ONE |
| title | Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. |
| title_full | Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. |
| title_fullStr | Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. |
| title_full_unstemmed | Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. |
| title_short | Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. |
| title_sort | genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change the diogenes study |
| url | http://europepmc.org/articles/PMC3044761?pdf=render |
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