Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models

Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models

Histone Deacetylase (HDAC) enzymes are upregulated in cancer leading to the development of HDAC inhibiting compounds, several of which are currently in clinical trials. Side effects associated with toxicity and non-specific targeting indicate the need for efficient drug delivery approaches and tumor...

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Bibliographic Details
Main Authors: Kadie Edwards, Seydou Yao, Simone Pisano, Veronica Feltracco, Katja Brusehafer, Sumanta Samanta, Oommen P. Oommen, S. Andrea Gazze, Roberta Paravati, Holly Maddison, Chao Li, Deyarina Gonzalez, R. Steven Conlan, Lewis Francis
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
polymeric nanoparticles
hyaluronic acid
epigenetics
SAHA
nanomedicines
gynecological oncology
Online Access:https://www.mdpi.com/2072-6694/13/16/4032

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