Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease.
Angiotensin converting enzyme (ACE) 2 is a negative regulator of the renin angiotensin system (RAS) through its role to degrade angiotensin II. In rats with subtotal nephrectomy (STNx), adverse cardiac remodelling occurs despite elevated cardiac ACE2 activity. We hypothesised that diminazene acetura...
Main Authors: | Elena Velkoska, Sheila K Patel, Karen Griggs, Louise M Burrell |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5003360?pdf=render |
Similar Items
-
Diminazene aceturate exacerbates renal fibrosis after unilateral ureteral obstruction in female mice
by: Yosep Kim, et al.
Published: (2023-03-01) -
Diminazene aceturate attenuates hepatic ischemia/reperfusion injury in mice
by: So Hye Yoon, et al.
Published: (2022-10-01) -
Effects of diminazene aceturate on flip-flop plasma pharmacokinetics of piroxicam in dogs
by: Saganuwan Alhaji Saganuwan, et al.
Published: (2023-11-01) -
β-Cyclodextrin as a Functional Excipient Used for Enhancing the Diminazene Aceturate Bioavailability
by: Narcisa Marangoci, et al.
Published: (2019-06-01) -
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model
by: Zhaoqing Lu, et al.
Published: (2022-07-01)