Repositioning of Old Drugs for Novel Cancer Therapies: Continuous Therapeutic Perfusion of Aspirin and Oseltamivir Phosphate with Gemcitabine Treatment Disables Tumor Progression, Chemoresistance, and Metastases

Repositioning of Old Drugs for Novel Cancer Therapies: Continuous Therapeutic Perfusion of Aspirin and Oseltamivir Phosphate with Gemcitabine Treatment Disables Tumor Progression, Chemoresistance, and Metastases

Metastatic pancreatic cancer has an invariably fatal outcome, with an estimated median progression-free survival of approximately six months employing our best combination chemotherapeutic regimens. Once drug resistance develops, manifested by increased primary tumor size and new and growing metasta...

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Bibliographic Details
Main Authors: Bessi Qorri, Reza Bayat Mokhtari, William W. Harless, Myron R. Szewczuk
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
osmotic pump
chemoresistance
drug repurposing
EMT
Online Access:https://www.mdpi.com/2072-6694/14/15/3595

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