Selenium nutritional status and thyroid dysfunction
ABSTRACT Selenium(Se) is an essential micronutrient for several immune and regulatory functions in the body. In thyroid tissue, Se contributes to the antioxidant system and is a crucial component of deiodinases, which are selenoproteins that participate in thyroid hormone metabolism. Additionally, t...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2025-03-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000101701&lng=en&tlng=en |
| _version_ | 1826552311704453120 |
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| author | Luciana Sant’Ana Leone de Souza Renata de Oliveira Campos Jair de Souza Braga Filho Joice dos Santos de Jesus Helton Estrela Ramos Sara Moreira Anunciação Jéssica Fernanda Cassemiro Pedro Resende Ferreira Rende Fábio Hecht |
| author_facet | Luciana Sant’Ana Leone de Souza Renata de Oliveira Campos Jair de Souza Braga Filho Joice dos Santos de Jesus Helton Estrela Ramos Sara Moreira Anunciação Jéssica Fernanda Cassemiro Pedro Resende Ferreira Rende Fábio Hecht |
| author_sort | Luciana Sant’Ana Leone de Souza |
| collection | DOAJ |
| description | ABSTRACT Selenium(Se) is an essential micronutrient for several immune and regulatory functions in the body. In thyroid tissue, Se contributes to the antioxidant system and is a crucial component of deiodinases, which are selenoproteins that participate in thyroid hormone metabolism. Additionally, this micronutrient exerts a significant impact on thyroid pathophysiology, as low levels of Se lead to reduced activity of glutathione peroxidase, a selenoprotein involved in antioxidative processes, thereby resulting in increased oxidative stress and damage to thyroid tissue. Selenium deficiency (SeD) can cause growth retardation and reproductive failure; in women and children, it may result in Keshan’s disease and Kashin-Beck’s disease. Research has shown an inverse correlation between Se serum levels and autoimmune thyroiditis in areas with mild SeD. In Graves’ disease, Se supplementation has been linked to faster achievement of euthyroidism as well as improvements in quality of life, lessened orbital involvement, and slower ocular progression of the disease. Furthermore, several studies suggest an association between serum SeD and the development of thyroid cancer. Maintaining physiological Se concentrations appears to be related to the prevention of thyroid disease, although current data are insufficient to conclusively support or refute the efficacy of supplementation. Through this narrative review, we aim to present the latest information on the role of selenium in thyroid pathophysiology. To identify relevant literature, specific search strategies were employed in the electronic databases PubMed, Lilacs, and SciELO. |
| first_indexed | 2025-03-14T07:07:07Z |
| format | Article |
| id | doaj.art-d9ae214d4d2f4d5b91d55aca23aec851 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2025-03-14T07:07:07Z |
| publishDate | 2025-03-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-d9ae214d4d2f4d5b91d55aca23aec8512025-03-04T07:45:24ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-03-0169110.20945/2359-4292-2023-0348Selenium nutritional status and thyroid dysfunctionLuciana Sant’Ana Leone de Souzahttps://orcid.org/0000-0003-2595-0603Renata de Oliveira Camposhttps://orcid.org/0000-0002-2888-4798Jair de Souza Braga Filhohttps://orcid.org/0000-0003-3846-7725Joice dos Santos de Jesushttps://orcid.org/0000-0002-4714-2415Helton Estrela Ramoshttps://orcid.org/0000-0002-2900-2099Sara Moreira Anunciaçãohttps://orcid.org/0000-0002-8080-4900Jéssica Fernanda Cassemirohttps://orcid.org/0000-0002-3119-769XPedro Resende Ferreira Rendehttps://orcid.org/0000-0001-8999-8871Fábio Hechthttps://orcid.org/0000-0001-9110-2587ABSTRACT Selenium(Se) is an essential micronutrient for several immune and regulatory functions in the body. In thyroid tissue, Se contributes to the antioxidant system and is a crucial component of deiodinases, which are selenoproteins that participate in thyroid hormone metabolism. Additionally, this micronutrient exerts a significant impact on thyroid pathophysiology, as low levels of Se lead to reduced activity of glutathione peroxidase, a selenoprotein involved in antioxidative processes, thereby resulting in increased oxidative stress and damage to thyroid tissue. Selenium deficiency (SeD) can cause growth retardation and reproductive failure; in women and children, it may result in Keshan’s disease and Kashin-Beck’s disease. Research has shown an inverse correlation between Se serum levels and autoimmune thyroiditis in areas with mild SeD. In Graves’ disease, Se supplementation has been linked to faster achievement of euthyroidism as well as improvements in quality of life, lessened orbital involvement, and slower ocular progression of the disease. Furthermore, several studies suggest an association between serum SeD and the development of thyroid cancer. Maintaining physiological Se concentrations appears to be related to the prevention of thyroid disease, although current data are insufficient to conclusively support or refute the efficacy of supplementation. Through this narrative review, we aim to present the latest information on the role of selenium in thyroid pathophysiology. To identify relevant literature, specific search strategies were employed in the electronic databases PubMed, Lilacs, and SciELO.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000101701&lng=en&tlng=enSeleniumthyroidselenium deficiency |
| spellingShingle | Luciana Sant’Ana Leone de Souza Renata de Oliveira Campos Jair de Souza Braga Filho Joice dos Santos de Jesus Helton Estrela Ramos Sara Moreira Anunciação Jéssica Fernanda Cassemiro Pedro Resende Ferreira Rende Fábio Hecht Selenium nutritional status and thyroid dysfunction Archives of Endocrinology and Metabolism Selenium thyroid selenium deficiency |
| title | Selenium nutritional status and thyroid dysfunction |
| title_full | Selenium nutritional status and thyroid dysfunction |
| title_fullStr | Selenium nutritional status and thyroid dysfunction |
| title_full_unstemmed | Selenium nutritional status and thyroid dysfunction |
| title_short | Selenium nutritional status and thyroid dysfunction |
| title_sort | selenium nutritional status and thyroid dysfunction |
| topic | Selenium thyroid selenium deficiency |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000101701&lng=en&tlng=en |
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