Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

ObjectiveCurrent knowledge on the actions of tofacitinib on cytokine signaling pathways in rheumatoid arthritis (RA) is based on in vitro studies. Our study is the first to examine the effects of tofacitinib treatment on Janus kinase (JAK) - signal transducer and activator of transcription (STAT) pa...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Maaria Palmroth, Krista Kuuliala, Ritva Peltomaa, Anniina Virtanen, Antti Kuuliala, Antti Kurttila, Anna Kinnunen, Marjatta Leirisalo-Repo, Olli Silvennoinen, Pia Isomäki
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Frontiers Media S.A. 2021-09-01
Цуврал:Frontiers in Immunology
Нөхцлүүд:
rheumatoid arthritis
cytokines
JAK inhibitor
monocytes
T cells
B cells
Онлайн хандалт:https://www.frontiersin.org/articles/10.3389/fimmu.2021.738481/full

Интернэт

https://www.frontiersin.org/articles/10.3389/fimmu.2021.738481/full

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