Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA network
Dysregulation of XIAP has been shown to affect the progression of a variety of cancers, including lung adenocarcinoma (LUAD). However, the function and mechanisms of XIAP in lung adenocarcinoma with brain metastasis (LUAD-BM) remains poorly understood. In this study, we analyzed the differential mRN...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.946253/full |
| _version_ | 1818489905538400256 |
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| author | Yingjing Wang Lu Shen Geng Li Jiayi Chen Rong Ge |
| author_facet | Yingjing Wang Lu Shen Geng Li Jiayi Chen Rong Ge |
| author_sort | Yingjing Wang |
| collection | DOAJ |
| description | Dysregulation of XIAP has been shown to affect the progression of a variety of cancers, including lung adenocarcinoma (LUAD). However, the function and mechanisms of XIAP in lung adenocarcinoma with brain metastasis (LUAD-BM) remains poorly understood. In this study, we analyzed the differential mRNA of 58 lung adenocarcinomas samples and 28 lung adenocarcinomas with brain metastases in GEO database. 191 differentially expressed mRNAs were significantly associated with immune response, the proliferation of the immune cell, cell-cell adhesion. Subsequent analyzed by lasso and SVM found that XIAP was significantly elevated in LUAD-BM and significantly associated with LUAD grade and metastasis. Then we constructed a molecular regulatory network of ncRNA-miRNA-mRNA ceRNA by Cystoscope based on the correlation obtained from Starbase. It was found that SBF2-AS1 or RUNDC3A-AS1, has-miR-338-3p and XIAP may have a regulatory relationship. Furthermore, we also initially found that XIAP was closely correlation with T cells, B cells, Mast cells, macrophages, and dendritic cells. In conclusion, we found that XIAP was significantly higher expressed in LUAD-BM compared with LUAD without brain metastasis, suggesting that XIAP may play an important role in the future prediction and clinical treatment of LUAD-BM. |
| first_indexed | 2024-12-10T17:10:06Z |
| format | Article |
| id | doaj.art-d9b0ac9396ad49d592f4b3037010e2ef |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T17:10:06Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d9b0ac9396ad49d592f4b3037010e2ef2022-12-22T01:40:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.946253946253Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA networkYingjing Wang0Lu Shen1Geng Li2Jiayi Chen3Rong Ge4Department of Diagnosis, Ningbo Diagnostic Pathology Center, Ningbo, ChinaHwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaDepartment of Diagnosis, Ningbo Diagnostic Pathology Center, Ningbo, ChinaDepartment of Diagnosis, Ningbo Diagnostic Pathology Center, Ningbo, ChinaDepartment of Diagnosis, Ningbo Diagnostic Pathology Center, Ningbo, ChinaDysregulation of XIAP has been shown to affect the progression of a variety of cancers, including lung adenocarcinoma (LUAD). However, the function and mechanisms of XIAP in lung adenocarcinoma with brain metastasis (LUAD-BM) remains poorly understood. In this study, we analyzed the differential mRNA of 58 lung adenocarcinomas samples and 28 lung adenocarcinomas with brain metastases in GEO database. 191 differentially expressed mRNAs were significantly associated with immune response, the proliferation of the immune cell, cell-cell adhesion. Subsequent analyzed by lasso and SVM found that XIAP was significantly elevated in LUAD-BM and significantly associated with LUAD grade and metastasis. Then we constructed a molecular regulatory network of ncRNA-miRNA-mRNA ceRNA by Cystoscope based on the correlation obtained from Starbase. It was found that SBF2-AS1 or RUNDC3A-AS1, has-miR-338-3p and XIAP may have a regulatory relationship. Furthermore, we also initially found that XIAP was closely correlation with T cells, B cells, Mast cells, macrophages, and dendritic cells. In conclusion, we found that XIAP was significantly higher expressed in LUAD-BM compared with LUAD without brain metastasis, suggesting that XIAP may play an important role in the future prediction and clinical treatment of LUAD-BM.https://www.frontiersin.org/articles/10.3389/fonc.2022.946253/fulllung adenocarcinomabrain metastasisXIAPhas-miR-338-3Pimmune infiltration |
| spellingShingle | Yingjing Wang Lu Shen Geng Li Jiayi Chen Rong Ge Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA network Frontiers in Oncology lung adenocarcinoma brain metastasis XIAP has-miR-338-3P immune infiltration |
| title | Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA network |
| title_full | Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA network |
| title_fullStr | Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA network |
| title_full_unstemmed | Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA network |
| title_short | Upregulation of XIAP promotes lung adenocarcinoma brain metastasis by modulating ceRNA network |
| title_sort | upregulation of xiap promotes lung adenocarcinoma brain metastasis by modulating cerna network |
| topic | lung adenocarcinoma brain metastasis XIAP has-miR-338-3P immune infiltration |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.946253/full |
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