Synthesis and In Silico Study of Some New <i>bis</i>-[1,3,4]thiadiazolimines and <i>bis</i>-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease

Synthesis and In Silico Study of Some New <i>bis</i>-[1,3,4]thiadiazolimines and <i>bis</i>-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease

A novel series of <i>bis</i>-[1,3,4]thiadiazolimines, and <i>bis</i>-thiazolimines, with alkyl linker, were synthesized through general routes from cyclization of 1,1′-(hexane-1,6-diyl)bis(3-phenylthiourea) and hydrazonoyl halides or <i>α</i>-haloketones, respecti...

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Main Authors: Sobhi M. Gomha, Sayed M. Riyadh, Magda H. Abdellattif, Tariq Z. Abolibda, Hassan M. Abdel-aziz, AbdElAziz. A. Nayl, Alaa M. Elgohary, Abdo A. Elfiky
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Current Issues in Molecular Biology
Subjects:
<i>bis</i>-(3-phenylthiourea)
hydrazonoyl halides
<i>α</i>-haloketones
molecular docking
SARS-CoV-2 M<sup>pro</sup>
Online Access:https://www.mdpi.com/1467-3045/44/10/311

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