Transduction of skeletal muscles with common reporter genes can promote muscle fiber degeneration and inflammation.

Transduction of skeletal muscles with common reporter genes can promote muscle fiber degeneration and inflammation.

Recombinant adeno-associated viral vectors (rAAV vectors) are promising tools for delivering transgenes to skeletal muscle, in order to study the mechanisms that control the muscle phenotype, and to ameliorate diseases that perturb muscle homeostasis. Many studies have employed rAAV vectors carrying...

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Bibliographic Details
Main Authors: Catherine E Winbanks, Claudia Beyer, Hongwei Qian, Paul Gregorevic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3520959?pdf=render

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