Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia
During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahyd...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622000212 |
| _version_ | 1811200727313285120 |
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| author | Dale W. Prebble Tanja M. Voser Safak Er Irena Hlushchuk Andrii Domanskyi Mikko Airavaara Merrick G. Ekins George D. Mellick Anthony R. Carroll |
| author_facet | Dale W. Prebble Tanja M. Voser Safak Er Irena Hlushchuk Andrii Domanskyi Mikko Airavaara Merrick G. Ekins George D. Mellick Anthony R. Carroll |
| author_sort | Dale W. Prebble |
| collection | DOAJ |
| description | During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the α-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2′-demethylaplysinopsin (4), 2-amino-4′-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and α-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) |
| first_indexed | 2024-04-12T02:08:23Z |
| format | Article |
| id | doaj.art-d9b1edf9ef4c4f8cb9d92ed987c40d02 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-12T02:08:23Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-d9b1edf9ef4c4f8cb9d92ed987c40d022022-12-22T03:52:28ZengElsevierResults in Chemistry2211-71562022-01-014100302Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperiaDale W. Prebble0Tanja M. Voser1Safak Er2Irena Hlushchuk3Andrii Domanskyi4Mikko Airavaara5Merrick G. Ekins6George D. Mellick7Anthony R. Carroll8School of Environment and Science, Griffith University (Gold Coast Campus), Parklands Drive, Southport, QLD 4222, Australia; Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, AustraliaSchool of Environment and Science, Griffith University (Gold Coast Campus), Parklands Drive, Southport, QLD 4222, AustraliaFaculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki 00014, FinlandFaculty of Pharmacy, University of Helsinki, Helsinki 00014, FinlandInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki 00014, FinlandFaculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland; Neuroscience Center, HiLIFE, University of Helsinki, Helsinki 00014, FinlandGriffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia; Queensland Museum, South Brisbane BC, QLD 4101, AustraliaSchool of Environment and Science, Griffith University (Gold Coast Campus), Parklands Drive, Southport, QLD 4222, Australia; Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, AustraliaSchool of Environment and Science, Griffith University (Gold Coast Campus), Parklands Drive, Southport, QLD 4222, Australia; Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia; Corresponding author at: School of Environment and Science, Griffith University (Gold Coast Campus), Parklands Drive, Southport, QLD 4222, Australia.During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the α-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2′-demethylaplysinopsin (4), 2-amino-4′-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and α-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2)http://www.sciencedirect.com/science/article/pii/S2211715622000212Amyloidα-SynucleinClathria (Thalysias) cf. hesperiaAlkaloids |
| spellingShingle | Dale W. Prebble Tanja M. Voser Safak Er Irena Hlushchuk Andrii Domanskyi Mikko Airavaara Merrick G. Ekins George D. Mellick Anthony R. Carroll Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia Results in Chemistry Amyloid α-Synuclein Clathria (Thalysias) cf. hesperia Alkaloids |
| title | Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia |
| title_full | Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia |
| title_fullStr | Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia |
| title_full_unstemmed | Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia |
| title_short | Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia |
| title_sort | hesperine a new imidazole alkaloid and α synuclein binding activity of 1 methyl 1 2 7 8 tetrahydro 2 8 dioxoadenosine from the marine sponge clathria thalysias cf hesperia |
| topic | Amyloid α-Synuclein Clathria (Thalysias) cf. hesperia Alkaloids |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622000212 |
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