The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECIL
Infections are one of the major cause of death in the patients with hemato-oncological cancer. The prevention and appropriate treatment of infections is lifesaving. Infectious Diseases Society of America (IDSA)-licensed guideline “Clinical practice guideline for the use of antimicrobial agents in ne...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2016-03-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
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| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2016-21-01-001-009.pdf |
| _version_ | 1797922280205975552 |
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| author | Bircan KAYAASLAN |
| author_facet | Bircan KAYAASLAN |
| author_sort | Bircan KAYAASLAN |
| collection | DOAJ |
| description | Infections are one of the major cause of death in the patients with hemato-oncological cancer. The prevention and appropriate treatment of infections is lifesaving. Infectious Diseases Society of America (IDSA)-licensed guideline “Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the IDSA” and “European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growingresistance: summary of the 2011 4th European Conference on Infections in Leukemia (ECIL)” written by the 4th ECIL expert group are two main guidelines that help clinicians for the diagnosis and treatment of infections in febril neutropenic patients and contribute to evidence-based medicine. The IDSA guideline is more comprehensive than the ECIL. The recommendations of two guidelines are mostly similar. However, there are differences in some issues between the two guidelines.
The risk stratification and empiric antibiotics recommendation are different. However, the main differences between the two guidelines result from their recommendations about the empiric antifungal indication and the discontinuation time of therapy. Empirical antifungal treatment is recommended in both febril patients who are clinically stabil or unstabil in the IDSA quideline, although ECIL guideline recommends empirical antifungal treatment in only febril patients who are clinically unstabil. IDSA guideline recommends clinicians to continue antibiotic treatment for at least the duration of neutropenia. However, ECIL guideline recommends to discontinue of antibiotics after 72 hours in neutropenic patients who are hemodynamically stable and afebrile for at least 48 hours, irrespective of neutrophil count. |
| first_indexed | 2024-04-10T14:30:02Z |
| format | Article |
| id | doaj.art-d9b20f08baf742e9848c28f305e19cd6 |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T14:30:02Z |
| publishDate | 2016-03-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-d9b20f08baf742e9848c28f305e19cd62023-02-15T16:08:53ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2016-03-0121119The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECILBircan KAYAASLAN0Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Yildirim Beyazit, Ankara, TurkeyInfections are one of the major cause of death in the patients with hemato-oncological cancer. The prevention and appropriate treatment of infections is lifesaving. Infectious Diseases Society of America (IDSA)-licensed guideline “Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the IDSA” and “European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growingresistance: summary of the 2011 4th European Conference on Infections in Leukemia (ECIL)” written by the 4th ECIL expert group are two main guidelines that help clinicians for the diagnosis and treatment of infections in febril neutropenic patients and contribute to evidence-based medicine. The IDSA guideline is more comprehensive than the ECIL. The recommendations of two guidelines are mostly similar. However, there are differences in some issues between the two guidelines. The risk stratification and empiric antibiotics recommendation are different. However, the main differences between the two guidelines result from their recommendations about the empiric antifungal indication and the discontinuation time of therapy. Empirical antifungal treatment is recommended in both febril patients who are clinically stabil or unstabil in the IDSA quideline, although ECIL guideline recommends empirical antifungal treatment in only febril patients who are clinically unstabil. IDSA guideline recommends clinicians to continue antibiotic treatment for at least the duration of neutropenia. However, ECIL guideline recommends to discontinue of antibiotics after 72 hours in neutropenic patients who are hemodynamically stable and afebrile for at least 48 hours, irrespective of neutrophil count.http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2016-21-01-001-009.pdfFebrilneutropenia |
| spellingShingle | Bircan KAYAASLAN The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECIL Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Febril neutropenia |
| title | The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECIL |
| title_full | The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECIL |
| title_fullStr | The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECIL |
| title_full_unstemmed | The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECIL |
| title_short | The Guidelines for Febril Neutropenic Patients: The Comparison of Guidelines of IDSA and ECIL |
| title_sort | guidelines for febril neutropenic patients the comparison of guidelines of idsa and ecil |
| topic | Febril neutropenia |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2016-21-01-001-009.pdf |
| work_keys_str_mv | AT bircankayaaslan theguidelinesforfebrilneutropenicpatientsthecomparisonofguidelinesofidsaandecil AT bircankayaaslan guidelinesforfebrilneutropenicpatientsthecomparisonofguidelinesofidsaandecil |