Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populations
Uric acid is the final metabolite of purine. Increased serum uric acid level is associated with incidence of gout and cardiovascular diseases. The aim of this study was to investigate the relationship between serum uric acid and parameters of biochemistry and haematology in Hangzhou populations, Chi...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2006-03-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://www.sjst.psu.ac.th/journal/28_suppl1_pdf/17_Hangzhou_populations.pdf |
| _version_ | 1818207697214898176 |
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| author | Jiajin Zhu Ting Yao Yonghua Zhang Xiaoqun Zhou Xiaomei Yu Sirithon Siriamornpun Andrew J. Sinclair Duo Li |
| author_facet | Jiajin Zhu Ting Yao Yonghua Zhang Xiaoqun Zhou Xiaomei Yu Sirithon Siriamornpun Andrew J. Sinclair Duo Li |
| author_sort | Jiajin Zhu |
| collection | DOAJ |
| description | Uric acid is the final metabolite of purine. Increased serum uric acid level is associated with incidence of gout and cardiovascular diseases. The aim of this study was to investigate the relationship between serum uric acid and parameters of biochemistry and haematology in Hangzhou populations, China. In this crosssectional study, 186 male (56±14 y) and 85 female (55±11 y) free-living subjects were recruited from Hangzhou, China. The physiological parameters were measured. Each subject gave fasting blood, urine and faeces samples, from which serum uric acid and other parameters of biochemistry and haematology were measured with standard methods. Serum uric concentration was significantly higher in males than in females, 329±69 µmol/L for male and 237±53 µmol/L for female (P<0.0001). Compared with female subjects, male had significantly higher BMI (P = 0.0215), serum TAG (P = 0.0012) and creatinine (P<0.0001), significantly lower TC (P = 0.0013) and HDL-C (P<0.0001). Bivariate analysis results showed that serum uric acid was significantly positively correlated with age (r = 0.171, P = 0.0076), BMI (r = 0.343, P<0.0001), systolic blood pressure (r = 0.234, P = 0.0002), diastolic blood pressure (r = 0.204, P = 0.0014), blood urea nitrogen (r = 0.251, P<0.0001), serum concentrations of total cholesterol (r = 0.192, P = 0.0026) and triacylglycerol (r = 0.306, P<0.0001), and significantly negatively correlated with HDL-cholesterol (r = -0.381, P<0.0001). In the bivariate analysis for separate gender, serum uric acid concentration was significantly positively correlated with TC (r = 0.255, P = 0.001), LDL-C (r = 0.329, P<0.0001) and HDL-C (r = -0.185, P = 0.0181) for males, but not for females. Serum uric acid concentration was significantly positively correlated with age for females (r = 0.289, P = 0.0081), but not for males. The results from the present study indicated that increased serum uric acid concentration was associated with a cluster of the cardiovascular risk factors in Hangzhou populations. |
| first_indexed | 2024-12-12T04:33:02Z |
| format | Article |
| id | doaj.art-d9b7235eb3eb40d7aac5b0414fc4e0e0 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-12-12T04:33:02Z |
| publishDate | 2006-03-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-d9b7235eb3eb40d7aac5b0414fc4e0e02022-12-22T00:38:02ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952006-03-0128Suppl.1133137Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populationsJiajin ZhuTing YaoYonghua ZhangXiaoqun ZhouXiaomei YuSirithon SiriamornpunAndrew J. SinclairDuo LiUric acid is the final metabolite of purine. Increased serum uric acid level is associated with incidence of gout and cardiovascular diseases. The aim of this study was to investigate the relationship between serum uric acid and parameters of biochemistry and haematology in Hangzhou populations, China. In this crosssectional study, 186 male (56±14 y) and 85 female (55±11 y) free-living subjects were recruited from Hangzhou, China. The physiological parameters were measured. Each subject gave fasting blood, urine and faeces samples, from which serum uric acid and other parameters of biochemistry and haematology were measured with standard methods. Serum uric concentration was significantly higher in males than in females, 329±69 µmol/L for male and 237±53 µmol/L for female (P<0.0001). Compared with female subjects, male had significantly higher BMI (P = 0.0215), serum TAG (P = 0.0012) and creatinine (P<0.0001), significantly lower TC (P = 0.0013) and HDL-C (P<0.0001). Bivariate analysis results showed that serum uric acid was significantly positively correlated with age (r = 0.171, P = 0.0076), BMI (r = 0.343, P<0.0001), systolic blood pressure (r = 0.234, P = 0.0002), diastolic blood pressure (r = 0.204, P = 0.0014), blood urea nitrogen (r = 0.251, P<0.0001), serum concentrations of total cholesterol (r = 0.192, P = 0.0026) and triacylglycerol (r = 0.306, P<0.0001), and significantly negatively correlated with HDL-cholesterol (r = -0.381, P<0.0001). In the bivariate analysis for separate gender, serum uric acid concentration was significantly positively correlated with TC (r = 0.255, P = 0.001), LDL-C (r = 0.329, P<0.0001) and HDL-C (r = -0.185, P = 0.0181) for males, but not for females. Serum uric acid concentration was significantly positively correlated with age for females (r = 0.289, P = 0.0081), but not for males. The results from the present study indicated that increased serum uric acid concentration was associated with a cluster of the cardiovascular risk factors in Hangzhou populations.http://www.sjst.psu.ac.th/journal/28_suppl1_pdf/17_Hangzhou_populations.pdfuric acidcorrelationcardiovascular risk factorsHangzhou |
| spellingShingle | Jiajin Zhu Ting Yao Yonghua Zhang Xiaoqun Zhou Xiaomei Yu Sirithon Siriamornpun Andrew J. Sinclair Duo Li Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populations Songklanakarin Journal of Science and Technology (SJST) uric acid correlation cardiovascular risk factors Hangzhou |
| title | Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populations |
| title_full | Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populations |
| title_fullStr | Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populations |
| title_full_unstemmed | Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populations |
| title_short | Relationship between serum uric acid and selected cardiovascular risk factors in Hangzhou populations |
| title_sort | relationship between serum uric acid and selected cardiovascular risk factors in hangzhou populations |
| topic | uric acid correlation cardiovascular risk factors Hangzhou |
| url | http://www.sjst.psu.ac.th/journal/28_suppl1_pdf/17_Hangzhou_populations.pdf |
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