What methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic review
Abstract Background The group-based trajectory modeling (GBTM) method is increasingly used in pharmacoepidemiologic studies to describe medication adherence trajectories over time. However, assessing the associations between these medication adherence trajectories and health-related outcomes remains...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-05-01
|
| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-022-01971-y |
| _version_ | 1818206660548624384 |
|---|---|
| author | Victoria Memoli Giraud Ekanmian Carlotta Lunghi Anne-Déborah Bouhnik Sophie Lauzier Line Guénette |
| author_facet | Victoria Memoli Giraud Ekanmian Carlotta Lunghi Anne-Déborah Bouhnik Sophie Lauzier Line Guénette |
| author_sort | Victoria Memoli |
| collection | DOAJ |
| description | Abstract Background The group-based trajectory modeling (GBTM) method is increasingly used in pharmacoepidemiologic studies to describe medication adherence trajectories over time. However, assessing the associations between these medication adherence trajectories and health-related outcomes remains challenging. The purpose of this review is to identify and systematically review the methods used to assess the association between medication adherence trajectories, estimated from the GBTM method, and health-related outcomes. Methods We will conduct a systematic review according to the recommendations of the Cochrane handbook for systematic reviews of interventions 6.2. Results will be reported following PRISMA 2020 (Preferred Reporting Items for Systematic Reviews and Meta-analyses) recommendations. We will search in the following databases: PubMed, Embase, PsycINFO, Web of Science, CINAHL, and Cochrane Library. Two reviewers will independently select articles and extract data. Discrepancies at every step will be resolved through discussion, and consensus will be reached for all disagreed articles. A third reviewer will act as a referee if needed. We will produce tables to synthesize the modalities used to estimate medication adherence trajectories with GBTM. We will also synthesize the modalities used to assess the association between these medication adherence trajectories and health-related outcomes by identifying the types of health-related outcomes studied and how they are defined, the statistical models used, and how the medication adherence trajectories were used in these models, and the effect measure yield. We will also review the limitations and biases reported by the authors and their attempts to mitigate them. We will provide a narrative synthesis. Discussion This review will provide a thorough exploration of the strategies and methods used in medication adherence research to estimate the associations between medication adherence trajectories, estimated with GBTM, and the different health-related outcomes. It will represent the first crucial steps toward optimizing these methods in adherence studies. Systematic review registration Prospero CRD42021213503 . |
| first_indexed | 2024-12-12T04:16:34Z |
| format | Article |
| id | doaj.art-d9b9129825b642b0bbc3573b7a88be13 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-12T04:16:34Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-d9b9129825b642b0bbc3573b7a88be132022-12-22T00:38:26ZengBMCSystematic Reviews2046-40532022-05-011111710.1186/s13643-022-01971-yWhat methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic reviewVictoria Memoli0Giraud Ekanmian1Carlotta Lunghi2Anne-Déborah Bouhnik3Sophie Lauzier4Line Guénette5Aix Marseille Univ, INSERM, IRD, SESSTIM, ISSPAM, Cancer, Biomedicine & Society Group, Equipe Labellisée Ligue Contre le CancerPopulation Health and Optimal Health Practices Research Axis, CHU de Québec-Université Laval Research CenterPopulation Health and Optimal Health Practices Research Axis, CHU de Québec-Université Laval Research CenterAix Marseille Univ, INSERM, IRD, SESSTIM, ISSPAM, Cancer, Biomedicine & Society Group, Equipe Labellisée Ligue Contre le CancerFaculty of Pharmacy, Université LavalPopulation Health and Optimal Health Practices Research Axis, CHU de Québec-Université Laval Research CenterAbstract Background The group-based trajectory modeling (GBTM) method is increasingly used in pharmacoepidemiologic studies to describe medication adherence trajectories over time. However, assessing the associations between these medication adherence trajectories and health-related outcomes remains challenging. The purpose of this review is to identify and systematically review the methods used to assess the association between medication adherence trajectories, estimated from the GBTM method, and health-related outcomes. Methods We will conduct a systematic review according to the recommendations of the Cochrane handbook for systematic reviews of interventions 6.2. Results will be reported following PRISMA 2020 (Preferred Reporting Items for Systematic Reviews and Meta-analyses) recommendations. We will search in the following databases: PubMed, Embase, PsycINFO, Web of Science, CINAHL, and Cochrane Library. Two reviewers will independently select articles and extract data. Discrepancies at every step will be resolved through discussion, and consensus will be reached for all disagreed articles. A third reviewer will act as a referee if needed. We will produce tables to synthesize the modalities used to estimate medication adherence trajectories with GBTM. We will also synthesize the modalities used to assess the association between these medication adherence trajectories and health-related outcomes by identifying the types of health-related outcomes studied and how they are defined, the statistical models used, and how the medication adherence trajectories were used in these models, and the effect measure yield. We will also review the limitations and biases reported by the authors and their attempts to mitigate them. We will provide a narrative synthesis. Discussion This review will provide a thorough exploration of the strategies and methods used in medication adherence research to estimate the associations between medication adherence trajectories, estimated with GBTM, and the different health-related outcomes. It will represent the first crucial steps toward optimizing these methods in adherence studies. Systematic review registration Prospero CRD42021213503 .https://doi.org/10.1186/s13643-022-01971-yGBTMGroup-based trajectory modelingMedication adherenceLatent class analysisLCALatent class growth analysis |
| spellingShingle | Victoria Memoli Giraud Ekanmian Carlotta Lunghi Anne-Déborah Bouhnik Sophie Lauzier Line Guénette What methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic review Systematic Reviews GBTM Group-based trajectory modeling Medication adherence Latent class analysis LCA Latent class growth analysis |
| title | What methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic review |
| title_full | What methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic review |
| title_fullStr | What methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic review |
| title_full_unstemmed | What methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic review |
| title_short | What methods are used to study the association between medication adherence trajectories, estimated with the group-based trajectory modeling (GBTM) method, and health-related outcomes?—a protocol for a systematic review |
| title_sort | what methods are used to study the association between medication adherence trajectories estimated with the group based trajectory modeling gbtm method and health related outcomes a protocol for a systematic review |
| topic | GBTM Group-based trajectory modeling Medication adherence Latent class analysis LCA Latent class growth analysis |
| url | https://doi.org/10.1186/s13643-022-01971-y |
| work_keys_str_mv | AT victoriamemoli whatmethodsareusedtostudytheassociationbetweenmedicationadherencetrajectoriesestimatedwiththegroupbasedtrajectorymodelinggbtmmethodandhealthrelatedoutcomesaprotocolforasystematicreview AT giraudekanmian whatmethodsareusedtostudytheassociationbetweenmedicationadherencetrajectoriesestimatedwiththegroupbasedtrajectorymodelinggbtmmethodandhealthrelatedoutcomesaprotocolforasystematicreview AT carlottalunghi whatmethodsareusedtostudytheassociationbetweenmedicationadherencetrajectoriesestimatedwiththegroupbasedtrajectorymodelinggbtmmethodandhealthrelatedoutcomesaprotocolforasystematicreview AT annedeborahbouhnik whatmethodsareusedtostudytheassociationbetweenmedicationadherencetrajectoriesestimatedwiththegroupbasedtrajectorymodelinggbtmmethodandhealthrelatedoutcomesaprotocolforasystematicreview AT sophielauzier whatmethodsareusedtostudytheassociationbetweenmedicationadherencetrajectoriesestimatedwiththegroupbasedtrajectorymodelinggbtmmethodandhealthrelatedoutcomesaprotocolforasystematicreview AT lineguenette whatmethodsareusedtostudytheassociationbetweenmedicationadherencetrajectoriesestimatedwiththegroupbasedtrajectorymodelinggbtmmethodandhealthrelatedoutcomesaprotocolforasystematicreview |