Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis
Background: C-reactive protein (CRP) has been proposed as a risk marker and risk factor of cardiovascular disease. There have been a number of clinical reports suggesting that supplementation with L-carnitine can modulate systemic inflammation and lower circulating CRP concentrations, but the result...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2015-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2015/1452-82581502151S.pdf |
| _version_ | 1818328417950498816 |
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| author | Sahebkar Amirhossein |
| author_facet | Sahebkar Amirhossein |
| author_sort | Sahebkar Amirhossein |
| collection | DOAJ |
| description | Background: C-reactive protein (CRP) has been proposed as a risk marker and risk factor of cardiovascular disease. There have been a number of clinical reports suggesting that supplementation with L-carnitine can modulate systemic inflammation and lower circulating CRP concentrations, but the results have not been consistent. Methods: A comprehensive literature search in Medline, Scopus and Cochrane Central Register of Controlled Trials was performed in December 2012 to identify clinical trials investigating the impact of oral L-carnitine supplementation on serum/plasma CRP concentration. A random effect method was used to calculate the combined effect size. Results: Six studies comprising 541 cases and 546 controls met the inclusion criteria. Meta-analysis of included trials revealed a significant reduction of circulating CRP concentrations in subjects under L-carnitine intervention compared to the control treatment. The calculated combined weighted mean reduction in CRP concentrations was -0.39 mg/L [95% CI (-0.62 - -0.16)]. This effect size estimate was found to be robust and remained unaffected by the removal of each single study. Conclusions: The overall findings of the present metaanalysis support the clinically relevant benefit of L-carnitine supplementation in lowering the circulating levels of CRP. |
| first_indexed | 2024-12-13T12:31:50Z |
| format | Article |
| id | doaj.art-d9ba27f0c6f14ae9b6c66fba7746cb7a |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-13T12:31:50Z |
| publishDate | 2015-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-d9ba27f0c6f14ae9b6c66fba7746cb7a2022-12-21T23:46:00ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662015-01-013421511591452-82581502151SEffect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysisSahebkar Amirhossein0Mashhad University of Medical Sciences, Biotechnology Research Center, Mashhad, IranBackground: C-reactive protein (CRP) has been proposed as a risk marker and risk factor of cardiovascular disease. There have been a number of clinical reports suggesting that supplementation with L-carnitine can modulate systemic inflammation and lower circulating CRP concentrations, but the results have not been consistent. Methods: A comprehensive literature search in Medline, Scopus and Cochrane Central Register of Controlled Trials was performed in December 2012 to identify clinical trials investigating the impact of oral L-carnitine supplementation on serum/plasma CRP concentration. A random effect method was used to calculate the combined effect size. Results: Six studies comprising 541 cases and 546 controls met the inclusion criteria. Meta-analysis of included trials revealed a significant reduction of circulating CRP concentrations in subjects under L-carnitine intervention compared to the control treatment. The calculated combined weighted mean reduction in CRP concentrations was -0.39 mg/L [95% CI (-0.62 - -0.16)]. This effect size estimate was found to be robust and remained unaffected by the removal of each single study. Conclusions: The overall findings of the present metaanalysis support the clinically relevant benefit of L-carnitine supplementation in lowering the circulating levels of CRP.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2015/1452-82581502151S.pdfcarnitinenutritioncoronary artery diseaseatherosclerosissystematic reviewclinical trial |
| spellingShingle | Sahebkar Amirhossein Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis Journal of Medical Biochemistry carnitine nutrition coronary artery disease atherosclerosis systematic review clinical trial |
| title | Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis |
| title_full | Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis |
| title_fullStr | Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis |
| title_full_unstemmed | Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis |
| title_short | Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis |
| title_sort | effect of l carnitine supplementation on circulating c reactive protein levels a systematic review and meta analysis |
| topic | carnitine nutrition coronary artery disease atherosclerosis systematic review clinical trial |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2015/1452-82581502151S.pdf |
| work_keys_str_mv | AT sahebkaramirhossein effectoflcarnitinesupplementationoncirculatingcreactiveproteinlevelsasystematicreviewandmetaanalysis |