Immunogenicity of small‐cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition

Immunogenicity of small‐cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition

Abstract Introduction The activation of STING (stimulator of interferon genes) pathway enhances antitumor immunity in small‐cell lung cancer (SCLC), while the DNA damage induced by non‐cGAMP‐based agonists is a potent inducer of STING activity. Here, we investigate the intrinsic expression of STING...

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Bibliographic Details
Main Authors: Xuetao Li, Yujun Li, Ziwen Zhao, Nabo Miao, Guorong Liu, Liaoyuan Deng, Shuquan Wei, Jun Hou
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Cancer Medicine
Subjects:
cGAS‐STING pathway
DNA damage response
immune infiltration
small‐cell lung cancer
type I IFNs
Online Access:https://doi.org/10.1002/cam4.5109

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