Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis
Abstract Background T1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software equipment, limiting the comparability of results. The aim was to test if...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12968-019-0595-7 |
| _version_ | 1797203261518774272 |
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| author | Riccardo Kranzusch Fabian aus dem Siepen Stephanie Wiesemann Leonora Zange Sarah Jeuthe Tiago Ferreira da Silva Titus Kuehne Burkert Pieske Christoph Tillmanns Matthias G. Friedrich Jeanette Schulz-Menger Daniel R. Messroghli |
| author_facet | Riccardo Kranzusch Fabian aus dem Siepen Stephanie Wiesemann Leonora Zange Sarah Jeuthe Tiago Ferreira da Silva Titus Kuehne Burkert Pieske Christoph Tillmanns Matthias G. Friedrich Jeanette Schulz-Menger Daniel R. Messroghli |
| author_sort | Riccardo Kranzusch |
| collection | DOAJ |
| description | Abstract Background T1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software equipment, limiting the comparability of results. The aim was to test if Z-scores can be used to compare the results of MOLLI T1 mapping from different cardiovascular magnetic resonance (CMR) platforms. Methods First, healthy subjects (n = 15) underwent 11 combinations of native short-axis T1 mapping (four CMR systems from two manufacturers at 1.5 T and 3 T, three MOLLI schemes). Mean and standard deviation (SD) of septal myocardial T1 were derived for each combination. T1 maps were transformed into Z-score maps based on mean and SD values using a prototype post-processing module. Second, Z-score mapping was applied to a validation sample of patients with cardiac amyloidosis at 1.5 T (n = 25) or 3 T (n = 13). Results In conventional T1 analysis, results were confounded by variations in field strength, MOLLI scheme, and manufacturer-specific system characteristics. Z-score-based analysis yielded consistent results without significant differences between any two of the combinations in part 1 of the study. In the validation sample, Z-score mapping differentiated between patients with cardiac amyloidosis and healthy subjects with the same diagnostic accuracy as standard T1 analysis regardless of field strength. Conclusions T1 analysis based on Z-score mapping provides consistent results without significant differences due to field strengths, CMR systems, or MOLLI variants, and detects cardiac amyloidosis with the same diagnostic accuracy as conventional T1 analysis. Z-score mapping provides a means to compare native T1 results acquired with MOLLI across different CMR platforms. |
| first_indexed | 2024-04-24T08:16:31Z |
| format | Article |
| id | doaj.art-d9c114f3b7174d5291ff933ce4f590ba |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:16:31Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-d9c114f3b7174d5291ff933ce4f590ba2024-04-17T03:46:52ZengElsevierJournal of Cardiovascular Magnetic Resonance1532-429X2020-01-0122111010.1186/s12968-019-0595-7Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosisRiccardo Kranzusch0Fabian aus dem Siepen1Stephanie Wiesemann2Leonora Zange3Sarah Jeuthe4Tiago Ferreira da Silva5Titus Kuehne6Burkert Pieske7Christoph Tillmanns8Matthias G. Friedrich9Jeanette Schulz-Menger10Daniel R. Messroghli11Department of Internal Medicine – Cardiology, Deutsches Herzzentrum BerlinDepartment of Cardiology, Angiology and Pneumology, Universitätsklinikum HeidelbergExperimental and Clinical Research Centera joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine and HELIOS Hospital Berlin BuchExperimental and Clinical Research Centera joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine and HELIOS Hospital Berlin BuchDepartment of Internal Medicine – Cardiology, Deutsches Herzzentrum BerlinDepartment of Congenital Heart Disease and Paediatric Cardiology, Charité – Universitätsmedizin BerlinGerman Center for Cardiovascular Research (DZHK), partner site BerlinDepartment of Internal Medicine – Cardiology, Deutsches Herzzentrum BerlinDiagnostikum BerlinDepartment of Cardiology, Angiology and Pneumology, Universitätsklinikum HeidelbergExperimental and Clinical Research Centera joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine and HELIOS Hospital Berlin BuchDepartment of Internal Medicine – Cardiology, Deutsches Herzzentrum BerlinAbstract Background T1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software equipment, limiting the comparability of results. The aim was to test if Z-scores can be used to compare the results of MOLLI T1 mapping from different cardiovascular magnetic resonance (CMR) platforms. Methods First, healthy subjects (n = 15) underwent 11 combinations of native short-axis T1 mapping (four CMR systems from two manufacturers at 1.5 T and 3 T, three MOLLI schemes). Mean and standard deviation (SD) of septal myocardial T1 were derived for each combination. T1 maps were transformed into Z-score maps based on mean and SD values using a prototype post-processing module. Second, Z-score mapping was applied to a validation sample of patients with cardiac amyloidosis at 1.5 T (n = 25) or 3 T (n = 13). Results In conventional T1 analysis, results were confounded by variations in field strength, MOLLI scheme, and manufacturer-specific system characteristics. Z-score-based analysis yielded consistent results without significant differences between any two of the combinations in part 1 of the study. In the validation sample, Z-score mapping differentiated between patients with cardiac amyloidosis and healthy subjects with the same diagnostic accuracy as standard T1 analysis regardless of field strength. Conclusions T1 analysis based on Z-score mapping provides consistent results without significant differences due to field strengths, CMR systems, or MOLLI variants, and detects cardiac amyloidosis with the same diagnostic accuracy as conventional T1 analysis. Z-score mapping provides a means to compare native T1 results acquired with MOLLI across different CMR platforms.https://doi.org/10.1186/s12968-019-0595-7Myocardial diseaseTissue analysisMagnetic resonance imagingT1 mappingStandardizationZ-score |
| spellingShingle | Riccardo Kranzusch Fabian aus dem Siepen Stephanie Wiesemann Leonora Zange Sarah Jeuthe Tiago Ferreira da Silva Titus Kuehne Burkert Pieske Christoph Tillmanns Matthias G. Friedrich Jeanette Schulz-Menger Daniel R. Messroghli Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis Journal of Cardiovascular Magnetic Resonance Myocardial disease Tissue analysis Magnetic resonance imaging T1 mapping Standardization Z-score |
| title | Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis |
| title_full | Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis |
| title_fullStr | Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis |
| title_full_unstemmed | Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis |
| title_short | Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis |
| title_sort | z score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified look locker inversion recovery molli t1 data normal behavior and validation in patients with amyloidosis |
| topic | Myocardial disease Tissue analysis Magnetic resonance imaging T1 mapping Standardization Z-score |
| url | https://doi.org/10.1186/s12968-019-0595-7 |
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