Profiling FLT3 Mutations in Mexican Acute Myeloid Leukemia Pediatric Patients: Impact on Overall Survival

Profiling FLT3 Mutations in Mexican Acute Myeloid Leukemia Pediatric Patients: Impact on Overall Survival

Background: Acute myeloid leukemia (AML) is the second most frequent leukemia in childhood. The FLT3 gene participates in hematopoietic stem cell proliferation. FLT3 mutations are recurrent in AML and influence prognosis. In Mexican pediatric AML patients, FLT3 mutational profile, and their clinical...

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Main Authors: Carolina Molina Garay, Karol Carrillo Sánchez, Luis Leonardo Flores Lagunes, Marco Jiménez Olivares, Anallely Muñoz Rivas, Beatríz Eugenia Villegas Torres, Hilario Flores Aguilar, Juan Carlos Núñez Enríquez, Elva Jiménez Hernández, Vilma Carolina Bekker Méndez, José Refugio Torres Nava, Janet Flores Lujano, Jorge Alfonso Martín Trejo, Minerva Mata Rocha, Aurora Medina Sansón, Laura Eugenia Espinoza Hernández, José Gabriel Peñaloza Gonzalez, Rosa Martha Espinosa Elizondo, Luz Victoria Flores Villegas, Raquel Amador Sanchez, Maria Luisa Pérez Saldívar, Omar Alejandro Sepúlveda Robles, Haydeé Rosas Vargas, Angélica Rangel López, María Lilia Domínguez López, Ethel Awilda García Latorre, Elba Reyes Maldonado, Patricia Galindo Delgado, Juan Manuel Mejía Aranguré, Carmen Alaez Verson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pediatrics
Subjects:
FLT3
pediatric
Mexican
AML
survival
risk-stratification
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00586/full

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