Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease
Background: HsCRP (Highly sensitive C reactive protein) is a global indicator for future vascular events in adults detected in blood stream 48 hours before the cardiovascular event. Periodontal disease may increase blood levels of inflammatory markers like IL-6, CRP and HsCRP. Hence the aim of the p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2015;volume=26;issue=5;spage=500;epage=503;aulast=Anitha |
| _version_ | 1819087676538617856 |
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| author | V Anitha Sushma Nair V Shivakumar M Shanmugam B Meena Priya P Rajesh |
| author_facet | V Anitha Sushma Nair V Shivakumar M Shanmugam B Meena Priya P Rajesh |
| author_sort | V Anitha |
| collection | DOAJ |
| description | Background: HsCRP (Highly sensitive C reactive protein) is a global indicator for future vascular events in adults detected in blood stream 48 hours before the cardiovascular event. Periodontal disease may increase blood levels of inflammatory markers like IL-6, CRP and HsCRP. Hence the aim of the present study is to evaluate the presence of elevated HsCRP levels in chronic periodontitis patients.
Material and Methods: 100 patients who reported for cardiac master health check up were enrolled in the study. The periodontal status was assessed using periodontal probing pocket depth and clinical attachment level. The decayed, missing and filled tooth was recorded using DMFT index. The venous samples of these patients were obtained for recording HsCRP levels.
Results: Pearson correlation was used to analyze the relationship between HsCRP level and probing pocket depth, clinical attachment loss and DMFT. The correlation value was 0.051, 0.025 and 0.101 respectively, the correlation is statistically significant for probing pocket depth and clinical attachment level (P>0.05). Chi- square test was performed to study the association between gender and HsCRP, Diabetes Mellitus and HsCRP and Hypertension and HsCRP; the results showed that there is no significant association between any of the above mentioned factors and HsCRP level in blood.
Conclusions: We found an increased level of HsCRP in patients with chronic periodontitis which revealed the susceptibility of these patients to cardiac diseases like myocardial infarction and stroke. Hence present day focus in the line of management of cardiac patient has changed from the periodontal perspective. |
| first_indexed | 2024-12-21T21:39:56Z |
| format | Article |
| id | doaj.art-d9c2a96a12a64137b62eca3dae482e19 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-12-21T21:39:56Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-d9c2a96a12a64137b62eca3dae482e192022-12-21T18:49:23ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032015-01-0126550050310.4103/0970-9290.172048Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery diseaseV AnithaSushma NairV ShivakumarM ShanmugamB Meena PriyaP RajeshBackground: HsCRP (Highly sensitive C reactive protein) is a global indicator for future vascular events in adults detected in blood stream 48 hours before the cardiovascular event. Periodontal disease may increase blood levels of inflammatory markers like IL-6, CRP and HsCRP. Hence the aim of the present study is to evaluate the presence of elevated HsCRP levels in chronic periodontitis patients. Material and Methods: 100 patients who reported for cardiac master health check up were enrolled in the study. The periodontal status was assessed using periodontal probing pocket depth and clinical attachment level. The decayed, missing and filled tooth was recorded using DMFT index. The venous samples of these patients were obtained for recording HsCRP levels. Results: Pearson correlation was used to analyze the relationship between HsCRP level and probing pocket depth, clinical attachment loss and DMFT. The correlation value was 0.051, 0.025 and 0.101 respectively, the correlation is statistically significant for probing pocket depth and clinical attachment level (P>0.05). Chi- square test was performed to study the association between gender and HsCRP, Diabetes Mellitus and HsCRP and Hypertension and HsCRP; the results showed that there is no significant association between any of the above mentioned factors and HsCRP level in blood. Conclusions: We found an increased level of HsCRP in patients with chronic periodontitis which revealed the susceptibility of these patients to cardiac diseases like myocardial infarction and stroke. Hence present day focus in the line of management of cardiac patient has changed from the periodontal perspective.http://www.ijdr.in/article.asp?issn=0970-9290;year=2015;volume=26;issue=5;spage=500;epage=503;aulast=AnithaCardiovascular diseasediabetes mellitusHsCRPperiodontal disease |
| spellingShingle | V Anitha Sushma Nair V Shivakumar M Shanmugam B Meena Priya P Rajesh Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease Indian Journal of Dental Research Cardiovascular disease diabetes mellitus HsCRP periodontal disease |
| title | Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease |
| title_full | Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease |
| title_fullStr | Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease |
| title_full_unstemmed | Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease |
| title_short | Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease |
| title_sort | estimation of high sensitivity c reactive protein in patients with periodontal disease and without coronary artery disease |
| topic | Cardiovascular disease diabetes mellitus HsCRP periodontal disease |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2015;volume=26;issue=5;spage=500;epage=503;aulast=Anitha |
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