Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review)
The metabolic processes of endo- and exogenous compounds play an important role in diagnosing and treating patients since many metabolites are laboratory biomarkers and/or targets for therapeutic agents. Cardiac troponins are one of the most critical biomarkers to diagnose cardiovascular diseases, i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/20/10928 |
| _version_ | 1797514406487130112 |
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| author | Aleksey M. Chaulin |
| author_facet | Aleksey M. Chaulin |
| author_sort | Aleksey M. Chaulin |
| collection | DOAJ |
| description | The metabolic processes of endo- and exogenous compounds play an important role in diagnosing and treating patients since many metabolites are laboratory biomarkers and/or targets for therapeutic agents. Cardiac troponins are one of the most critical biomarkers to diagnose cardiovascular diseases, including acute myocardial infarction. The study of troponin metabolism is of great interest as it opens up new possibilities for optimizing laboratory diagnostics. This article discusses in detail the key stages of the cardiac troponins metabolism, in particular the mechanisms of release from a healthy myocardium, mechanisms of circulation in the bloodstream, possible mechanisms of troponin penetration into other biological fluids (oral fluid, cerebrospinal fluid, pericardial and amniotic fluids), mechanisms of elimination of cardiac troponins from the blood, and daily changes in the levels of troponins in the blood. Considering these aspects of cardiac troponin metabolism, attention is focused on the potential value for clinical practice. |
| first_indexed | 2024-03-10T06:31:10Z |
| format | Article |
| id | doaj.art-d9c30eb548a84d72a30bc194f78e15a5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:31:10Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d9c30eb548a84d72a30bc194f78e15a52023-11-22T18:30:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201092810.3390/ijms222010928Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review)Aleksey M. Chaulin0Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, 443099 Samara, RussiaThe metabolic processes of endo- and exogenous compounds play an important role in diagnosing and treating patients since many metabolites are laboratory biomarkers and/or targets for therapeutic agents. Cardiac troponins are one of the most critical biomarkers to diagnose cardiovascular diseases, including acute myocardial infarction. The study of troponin metabolism is of great interest as it opens up new possibilities for optimizing laboratory diagnostics. This article discusses in detail the key stages of the cardiac troponins metabolism, in particular the mechanisms of release from a healthy myocardium, mechanisms of circulation in the bloodstream, possible mechanisms of troponin penetration into other biological fluids (oral fluid, cerebrospinal fluid, pericardial and amniotic fluids), mechanisms of elimination of cardiac troponins from the blood, and daily changes in the levels of troponins in the blood. Considering these aspects of cardiac troponin metabolism, attention is focused on the potential value for clinical practice.https://www.mdpi.com/1422-0067/22/20/10928cardiac troponinmetabolismmechanisms of troponin releasecirculationelimination of cardiac troponinscircadian |
| spellingShingle | Aleksey M. Chaulin Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review) International Journal of Molecular Sciences cardiac troponin metabolism mechanisms of troponin release circulation elimination of cardiac troponins circadian |
| title | Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review) |
| title_full | Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review) |
| title_fullStr | Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review) |
| title_full_unstemmed | Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review) |
| title_short | Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review) |
| title_sort | cardiac troponins metabolism from biochemical mechanisms to clinical practice literature review |
| topic | cardiac troponin metabolism mechanisms of troponin release circulation elimination of cardiac troponins circadian |
| url | https://www.mdpi.com/1422-0067/22/20/10928 |
| work_keys_str_mv | AT alekseymchaulin cardiactroponinsmetabolismfrombiochemicalmechanismstoclinicalpracticeliteraturereview |