Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis
IntroductionRheumatoid arthritis (RA), a prevailing chronic progressive autoimmune disease, seriously affects the patient's quality of life. However, there is still a lack of precise treatment and management methods in clinical practice. Previous studies showed that CD8+ T cells take a lead in...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044909/full |
| _version_ | 1811186778718076928 |
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| author | Zhenyu Zhao Jie Ren Siping Xie Longchun Zou Qianyue Zhao Shan Zeng Dingsheng Zha |
| author_facet | Zhenyu Zhao Jie Ren Siping Xie Longchun Zou Qianyue Zhao Shan Zeng Dingsheng Zha |
| author_sort | Zhenyu Zhao |
| collection | DOAJ |
| description | IntroductionRheumatoid arthritis (RA), a prevailing chronic progressive autoimmune disease, seriously affects the patient's quality of life. However, there is still a lack of precise treatment and management methods in clinical practice. Previous studies showed that CD8+ T cells take a lead in the progression of RA.MethodsGenes closely related to CD8+T cells in RA were identified through multiple RA datasets, CIBERSORT, and WGCNA algorithms. Further machine learning analysis were performed to identify CD8+T cell-related genes most closely related to RA. In addition, the relationship between these three key genes and 33 cancer species was also explored in this study.ResultsIn this study, 10 genes were identified to be closely related to CD8+T cells in RA. Machine learning analysis identified 3 CD8+T cell-related genes most closely related to RA: CD8A, GZMA, and PRF1.DiscussionOur research aims to provide new ideas for the clinical treatment of RA. |
| first_indexed | 2024-04-11T13:51:04Z |
| format | Article |
| id | doaj.art-d9c3d2b02c96446ab6b5d474dc2f0538 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T13:51:04Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d9c3d2b02c96446ab6b5d474dc2f05382022-12-22T04:20:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10449091044909Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysisZhenyu Zhao0Jie Ren1Siping Xie2Longchun Zou3Qianyue Zhao4Shan Zeng5Dingsheng Zha6Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Rheumatology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Medical Records, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaSchool of Stomatology, Jinan University, Guangzhou, ChinaSchool of Basic Medicine and Public Health, Jinan University, Guangzhou, ChinaDepartment of Rheumatology, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaIntroductionRheumatoid arthritis (RA), a prevailing chronic progressive autoimmune disease, seriously affects the patient's quality of life. However, there is still a lack of precise treatment and management methods in clinical practice. Previous studies showed that CD8+ T cells take a lead in the progression of RA.MethodsGenes closely related to CD8+T cells in RA were identified through multiple RA datasets, CIBERSORT, and WGCNA algorithms. Further machine learning analysis were performed to identify CD8+T cell-related genes most closely related to RA. In addition, the relationship between these three key genes and 33 cancer species was also explored in this study.ResultsIn this study, 10 genes were identified to be closely related to CD8+T cells in RA. Machine learning analysis identified 3 CD8+T cell-related genes most closely related to RA: CD8A, GZMA, and PRF1.DiscussionOur research aims to provide new ideas for the clinical treatment of RA.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044909/fullCD8+ T Cells1rheumatoid arthritis2WGCNA3Pan-Cancer4ssGSEA5 |
| spellingShingle | Zhenyu Zhao Jie Ren Siping Xie Longchun Zou Qianyue Zhao Shan Zeng Dingsheng Zha Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis Frontiers in Immunology CD8+ T Cells1 rheumatoid arthritis2 WGCNA3 Pan-Cancer4 ssGSEA5 |
| title | Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis |
| title_full | Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis |
| title_fullStr | Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis |
| title_full_unstemmed | Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis |
| title_short | Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis |
| title_sort | identification of biomarkers associated with cd8 t cells in rheumatoid arthritis and their pan cancer analysis |
| topic | CD8+ T Cells1 rheumatoid arthritis2 WGCNA3 Pan-Cancer4 ssGSEA5 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044909/full |
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