Copper-Binding Domain Variation in a Novel Murine Lysyl Oxidase Model Produces Structurally Inferior Aortic Elastic Fibers Whose Failure Is Modified by Age, Sex, and Blood Pressure

Copper-Binding Domain Variation in a Novel Murine Lysyl Oxidase Model Produces Structurally Inferior Aortic Elastic Fibers Whose Failure Is Modified by Age, Sex, and Blood Pressure

Lysyl oxidase (<i>LOX</i>) is a copper-binding enzyme that cross-links elastin and collagen. The dominant <i>LOX</i> variation contributes to familial thoracic aortic aneurysm. Previously reported murine <i>Lox</i> mutants had a mild phenotype and did not dilate w...

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Bibliographic Details
Main Authors: Kit Man Tsang, Russell H. Knutsen, Charles J. Billington, Eric Lindberg, Heiko Steenbock, Yi-Ping Fu, Amanda Wardlaw-Pickett, Delong Liu, Daniela Malide, Zu-Xi Yu, Christopher K. E. Bleck, Jürgen Brinckmann, Beth A. Kozel
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
lysyl oxidase
elastin
collagen
thoracic aortic aneurysm
sex as a biological variable
Fib-SEM
Online Access:https://www.mdpi.com/1422-0067/23/12/6749

Internet

https://www.mdpi.com/1422-0067/23/12/6749

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