Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model
The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs "per os" and 51 uninfected mice were considered as controls. Four hours post-...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-06-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000400009 |
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| author | Amélia Regina Semerene Ruy de Souza Lino Junior Jayrson Araújo Oliveira Albino Verçosa Magalhães Mariane Martins Araújo Stefani Alverne Passos Barbosa Dulcinéa Maria Barbosa Campos |
| author_facet | Amélia Regina Semerene Ruy de Souza Lino Junior Jayrson Araújo Oliveira Albino Verçosa Magalhães Mariane Martins Araújo Stefani Alverne Passos Barbosa Dulcinéa Maria Barbosa Campos |
| author_sort | Amélia Regina Semerene |
| collection | DOAJ |
| description | The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs "per os" and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells. |
| first_indexed | 2024-03-12T18:05:50Z |
| format | Article |
| id | doaj.art-d9c5effcf1ff416f91e3045e025537a7 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:50Z |
| publishDate | 2004-06-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-d9c5effcf1ff416f91e3045e025537a72023-08-02T09:28:35ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-06-0199439339810.1590/S0074-02762004000400009Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine modelAmélia Regina SemereneRuy de Souza Lino JuniorJayrson Araújo OliveiraAlbino Verçosa MagalhãesMariane Martins Araújo StefaniAlverne Passos BarbosaDulcinéa Maria Barbosa CamposThe goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs "per os" and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000400009Lagochilascaris minorexperimental infectioninflammatory response |
| spellingShingle | Amélia Regina Semerene Ruy de Souza Lino Junior Jayrson Araújo Oliveira Albino Verçosa Magalhães Mariane Martins Araújo Stefani Alverne Passos Barbosa Dulcinéa Maria Barbosa Campos Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model Memorias do Instituto Oswaldo Cruz Lagochilascaris minor experimental infection inflammatory response |
| title | Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model |
| title_full | Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model |
| title_fullStr | Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model |
| title_full_unstemmed | Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model |
| title_short | Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model |
| title_sort | experimental lagochilascariosis histopathological study of inflammatory response to larval migration in the murine model |
| topic | Lagochilascaris minor experimental infection inflammatory response |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000400009 |
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