Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report
Thrombotic complications in acute myeloid leukemia (AML) are uncommon due to coagulation dysfunction and thrombocytopenia. We report a unique case of AML presenting as concomitant pulmonary embolism and atypical acute myocardial infarction. A 67-year-old male experienced persistent bilateral chest p...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1259548/full |
| _version_ | 1797687014462586880 |
|---|---|
| author | Shuzhan Zheng Sha Luo Yong Luo Dan Liu Dan Liu Wenwu Zheng Qing Peng |
| author_facet | Shuzhan Zheng Sha Luo Yong Luo Dan Liu Dan Liu Wenwu Zheng Qing Peng |
| author_sort | Shuzhan Zheng |
| collection | DOAJ |
| description | Thrombotic complications in acute myeloid leukemia (AML) are uncommon due to coagulation dysfunction and thrombocytopenia. We report a unique case of AML presenting as concomitant pulmonary embolism and atypical acute myocardial infarction. A 67-year-old male experienced persistent bilateral chest pain. Despite an unremarkable electrocardiogram, elevated D-dimer and mildly increased troponin T levels prompted further investigation, leading to the diagnosis of simultaneous pulmonary embolism and acute myocardial infarction. The patient underwent percutaneous coronary intervention and received triple antithrombotic therapy. However, antithrombotic therapy was discontinued following a sharp decline in hemoglobin and platelet counts, and the patient subsequently developed persistent fever. AML was diagnosed via bone marrow biopsy. Chemotherapy was not initiated due to the patient's deteriorating condition, and he ultimately succumbed to presumed intracranial bleeding. |
| first_indexed | 2024-03-12T01:12:13Z |
| format | Article |
| id | doaj.art-d9c60afe15124429870db70b2fe33444 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T01:12:13Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-d9c60afe15124429870db70b2fe334442023-09-14T02:15:56ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-09-011010.3389/fcvm.2023.12595481259548Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case reportShuzhan Zheng0Sha Luo1Yong Luo2Dan Liu3Dan Liu4Wenwu Zheng5Qing Peng6Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaInflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThrombotic complications in acute myeloid leukemia (AML) are uncommon due to coagulation dysfunction and thrombocytopenia. We report a unique case of AML presenting as concomitant pulmonary embolism and atypical acute myocardial infarction. A 67-year-old male experienced persistent bilateral chest pain. Despite an unremarkable electrocardiogram, elevated D-dimer and mildly increased troponin T levels prompted further investigation, leading to the diagnosis of simultaneous pulmonary embolism and acute myocardial infarction. The patient underwent percutaneous coronary intervention and received triple antithrombotic therapy. However, antithrombotic therapy was discontinued following a sharp decline in hemoglobin and platelet counts, and the patient subsequently developed persistent fever. AML was diagnosed via bone marrow biopsy. Chemotherapy was not initiated due to the patient's deteriorating condition, and he ultimately succumbed to presumed intracranial bleeding.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1259548/fullacute myocardial infarctionpulmonary embolismacute myeloid leukemiathrombocytopeniapercutaneous coronary intervention |
| spellingShingle | Shuzhan Zheng Sha Luo Yong Luo Dan Liu Dan Liu Wenwu Zheng Qing Peng Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report Frontiers in Cardiovascular Medicine acute myocardial infarction pulmonary embolism acute myeloid leukemia thrombocytopenia percutaneous coronary intervention |
| title | Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report |
| title_full | Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report |
| title_fullStr | Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report |
| title_full_unstemmed | Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report |
| title_short | Acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia: a case report |
| title_sort | acute pulmonary embolism combined with acute myocardial infarction as the first manifestation of acute leukemia a case report |
| topic | acute myocardial infarction pulmonary embolism acute myeloid leukemia thrombocytopenia percutaneous coronary intervention |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1259548/full |
| work_keys_str_mv | AT shuzhanzheng acutepulmonaryembolismcombinedwithacutemyocardialinfarctionasthefirstmanifestationofacuteleukemiaacasereport AT shaluo acutepulmonaryembolismcombinedwithacutemyocardialinfarctionasthefirstmanifestationofacuteleukemiaacasereport AT yongluo acutepulmonaryembolismcombinedwithacutemyocardialinfarctionasthefirstmanifestationofacuteleukemiaacasereport AT danliu acutepulmonaryembolismcombinedwithacutemyocardialinfarctionasthefirstmanifestationofacuteleukemiaacasereport AT danliu acutepulmonaryembolismcombinedwithacutemyocardialinfarctionasthefirstmanifestationofacuteleukemiaacasereport AT wenwuzheng acutepulmonaryembolismcombinedwithacutemyocardialinfarctionasthefirstmanifestationofacuteleukemiaacasereport AT qingpeng acutepulmonaryembolismcombinedwithacutemyocardialinfarctionasthefirstmanifestationofacuteleukemiaacasereport |