INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE
Objective To investigate the influencing factors for serum 25-(OH)D level in very preterm infants at 4 weeks of age. Methods A total of 158 very preterm infants who were admitted to the neonatal intensive care unit of Qingdao Women and Children’s Hospital from January 2020 to October 2021 were enrol...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Precision Medicine
2023-02-01
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| Series: | 精准医学杂志 |
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| Online Access: | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/202301011.pdf |
| _version_ | 1797265428190330880 |
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| author | DENG Liping, ZHANG Liqin, SHAN Ruobing |
| author_facet | DENG Liping, ZHANG Liqin, SHAN Ruobing |
| author_sort | DENG Liping, ZHANG Liqin, SHAN Ruobing |
| collection | DOAJ |
| description | Objective To investigate the influencing factors for serum 25-(OH)D level in very preterm infants at 4 weeks of age. Methods A total of 158 very preterm infants who were admitted to the neonatal intensive care unit of Qingdao Women and Children’s Hospital from January 2020 to October 2021 were enrolled, and according to the serum 25-(OH)D level at 4 weeks of age, they were divided into sufficient group(≥75 nmol/L) and insufficient group (<75 nmol/L). The two groups were compared in terms of the general data of very preterm infants, maternal data, treatment measures, and complications, and the Logistic regression model was used to investigate the influencing factors for serum 25-(OH)D level in very preterm infants. Results Among the 158 very preterm infants, 72(45.6%) had a serum 25-(OH)D level of ≥75 nmol/L at 4 weeks of age and 86 (54.4%) had a serum 25-(OH)D level of <75 nmol/L. The multivariate analysis showed that birth in winter and spring (OR=4.900,P<0.05) and maternal gestational diabetes mellitus (OR=3.591,P<0.05) were independent influencing factors for serum 25-(OH)D level in very preterm infants at 4 weeks of age. Serum 25-(OH)D level in very preterm infants at 4 weeks of age was associated with the duration of intravenous vitamin D supplementation during hospitalization (OR=0.938,P<0.05). Conclusion There is a re-latively high incidence rate of vitamin D deficiency in very preterm infants at 4 weeks of age, and supplementation with vitamin D should begin as early as possible after birth. For very preterm infants with risk factors for vitamin D deficiency, vitamin D level should be monitored regularly and individualized vitamin D supplementation should be performed. |
| first_indexed | 2024-04-25T00:44:38Z |
| format | Article |
| id | doaj.art-d9c61df5b1494ac59e1c5671d114a6fd |
| institution | Directory Open Access Journal |
| issn | 2096-529X |
| language | zho |
| last_indexed | 2024-04-25T00:44:38Z |
| publishDate | 2023-02-01 |
| publisher | Editorial Office of Journal of Precision Medicine |
| record_format | Article |
| series | 精准医学杂志 |
| spelling | doaj.art-d9c61df5b1494ac59e1c5671d114a6fd2024-03-12T06:46:56ZzhoEditorial Office of Journal of Precision Medicine精准医学杂志2096-529X2023-02-01381394310.13362/j.jpmed.202301011INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGEDENG Liping, ZHANG Liqin, SHAN Ruobing0Neonatal Intensive Care Unit, Qingdao Women and Children’s Hospital, Qingdao University, Qingdao 266034, ChinaObjective To investigate the influencing factors for serum 25-(OH)D level in very preterm infants at 4 weeks of age. Methods A total of 158 very preterm infants who were admitted to the neonatal intensive care unit of Qingdao Women and Children’s Hospital from January 2020 to October 2021 were enrolled, and according to the serum 25-(OH)D level at 4 weeks of age, they were divided into sufficient group(≥75 nmol/L) and insufficient group (<75 nmol/L). The two groups were compared in terms of the general data of very preterm infants, maternal data, treatment measures, and complications, and the Logistic regression model was used to investigate the influencing factors for serum 25-(OH)D level in very preterm infants. Results Among the 158 very preterm infants, 72(45.6%) had a serum 25-(OH)D level of ≥75 nmol/L at 4 weeks of age and 86 (54.4%) had a serum 25-(OH)D level of <75 nmol/L. The multivariate analysis showed that birth in winter and spring (OR=4.900,P<0.05) and maternal gestational diabetes mellitus (OR=3.591,P<0.05) were independent influencing factors for serum 25-(OH)D level in very preterm infants at 4 weeks of age. Serum 25-(OH)D level in very preterm infants at 4 weeks of age was associated with the duration of intravenous vitamin D supplementation during hospitalization (OR=0.938,P<0.05). Conclusion There is a re-latively high incidence rate of vitamin D deficiency in very preterm infants at 4 weeks of age, and supplementation with vitamin D should begin as early as possible after birth. For very preterm infants with risk factors for vitamin D deficiency, vitamin D level should be monitored regularly and individualized vitamin D supplementation should be performed.https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/202301011.pdf25-hydroxyvitamin d|infant, premature|risk factors|time of birth|diabetes, gestational |
| spellingShingle | DENG Liping, ZHANG Liqin, SHAN Ruobing INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE 精准医学杂志 25-hydroxyvitamin d|infant, premature|risk factors|time of birth|diabetes, gestational |
| title | INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE |
| title_full | INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE |
| title_fullStr | INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE |
| title_full_unstemmed | INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE |
| title_short | INFLUENCING FACTORS FOR BLOOD 25-(OH)D LEVEL IN VERY PRETERM INFANTS AT 4 WEEKS OF AGE |
| title_sort | influencing factors for blood 25 oh d level in very preterm infants at 4 weeks of age |
| topic | 25-hydroxyvitamin d|infant, premature|risk factors|time of birth|diabetes, gestational |
| url | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/202301011.pdf |
| work_keys_str_mv | AT denglipingzhangliqinshanruobing influencingfactorsforblood25ohdlevelinverypreterminfantsat4weeksofage |