Summary: | Introduction: Down syndrome (DS) which is defined as
trisomy 21 is the most common chromosomal defect characterized by mental
retardation, hypotonia, dysmorphic facial features, and other distinctive
phenotypic characteristics. The prevalence of thyroid disorders in DS is 3% and
is significantly higher than in the normal population. In this study we aimed to investigate hematologic parameters
of children with DS who had and hadn’t subclinical hypothyroidism and compare
them with healthy controls. Methods:
This study included 184 patients who were followed up
with genetically diagnosed DS. Complete
blood count, levels of serum electrolytes, glucose, urea, liver function tests,
thyroid function tests were reviewed. Results: 102 (55.4%)
of the patients with DS were male and 82 (44.6%) were female. Mean age was 6.2
± 4.0 years. Control group was constituted of outpatient
healthy children. White blood cell count, hemoglobin, hematocrit, and
neutrophil counts were found to be significantly lower in patients with DS. Platelet count and plateletcrit levels were
found to be higher and platelet distribution width was lower in patients with
DS than in the control group.
Conclusion: We found significant differences among
hematological parameters in patients with DS. Subclinical
hypothyroidism
influences red blood cell distribution width, platelet count and MPV. Knowing
the incidence and severity of hematologic abnormalities in patients with DS will
be beneficial during follow-up in clinical practice.
|