Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells

Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells

Protein tau plays a pivotal role in the pathophysiology of Alzheimer's disease, where its hyperphos-phorylation promotes aggregation and microtubule destabilization. Tau undergoes alternative splicing which generates six isoforms in the human brain, due to inclusion/exclusion of exons 2, 3 and...

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Bibliographic Details
Main Authors:	TERESA LAGUNES, MARISOL HERRERA-RIVERO, MARÍA ELENA HERNÁNDEZ-AGUILAR, GONZALO E. ARANDA-ABREU
Format:	Article
Language:	English
Published:	Academia Brasileira de Ciências 2014-12-01
Series:	Anais da Academia Brasileira de Ciências
Subjects:	Doença de Alzheimer peptídeo amilóide regulação de splicing isoformas tau
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401927&lng=en&tlng=en

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