Structural Basis for Specific Recognition of Substrates by Sapovirus Protease

Structural Basis for Specific Recognition of Substrates by Sapovirus Protease

Sapovirus (SaV) protease catalyzes cleavage of the peptide bonds at six sites of a viral polyprotein for the viral replication and maturation. However, the mechanisms by which the protease recognizes the distinct sequences of the six cleavage sites remain poorly understood. Here we examined this i...

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Bibliographic Details
Main Authors: Masaru eYokoyama, Tomoichiro eOka, Hirotatsu eKojima, Tetsuo eNagano, Takayoshi eOkabe, Kazuhiko eKatayama, Takaji eWakita, Tadahito eKanda, Hironori eSato
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Microbiology
Subjects:
Mutagenesis
sapovirus protease
substrate recognition
P1 and P4 amino acids
3-D models
amino acid diversity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00312/full

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