Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study
Background: Conventional serum markers are routinely recommended to assess heart health. However, many new biochemical markers like lipoprotein-associated phospholipase A2 (Lp-PLA2) has been studied as an efficient cardiac risk marker. Our report is an attempt to present correlation between traditio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2019-05-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/22791 |
| _version_ | 1818309490096734208 |
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| author | Sandhya Iyer Rajkumar Kushawaha Prachi Sinkar Sivakumar Selvaraj Amruta Velumani |
| author_facet | Sandhya Iyer Rajkumar Kushawaha Prachi Sinkar Sivakumar Selvaraj Amruta Velumani |
| author_sort | Sandhya Iyer |
| collection | DOAJ |
| description | Background: Conventional serum markers are routinely recommended to assess heart health. However, many new biochemical markers like lipoprotein-associated phospholipase A2 (Lp-PLA2) has been studied as an efficient cardiac risk marker. Our report is an attempt to present correlation between traditional lipid markers and Lp-PLA2 in a pan-India cohort.
Materials and Methods: The study cohort included a total of 10347 pan-Indians including 5945 males and 4402 females respectively. The serum lipid parameters estimated include triglycerides, LDL- and HDL-cholesterol as well as total cholesterol by the technology of photometry.
Results: The frequency of high Lp-PLA2 detected in our study was 6.4% and the frequency between males at 9.3% and females at 2.5% was detected to be significant at p<0.0001. Linear regression analysis detected significant positive association of high Lp-PLA2 with LDL-cholesterol and total cholesterol at p<0.05, while the trend with HDL-cholesterol was also significant. However, Lp-PLA2 as an independent marker was not detected to be significant in relation to the lipid indices studied.
Conclusion: Though Lp-PLA2 has been associated with risk factor for acute coronary crisis, its clinical value remains controversial. Our report though detected significant association of Lp-PLA2 with various lipid parameters, independent value remains questionable. |
| first_indexed | 2024-12-13T07:30:59Z |
| format | Article |
| id | doaj.art-d9c8d518c900493f9ad59f29b5ffed22 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-13T07:30:59Z |
| publishDate | 2019-05-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-d9c8d518c900493f9ad59f29b5ffed222022-12-21T23:55:13ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762019-05-0110316https://doi.org/10.3126/ajms.v10i3.22791Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation studySandhya Iyer 0Rajkumar Kushawaha 1Prachi Sinkar 2Sivakumar Selvaraj 3Amruta Velumani 4Thyrocare Technologies Limited, IndiaThyrocare Technologies Limited, IndiaThyrocare Technologies Limited, IndiaThyrocare Technologies Limited, IndiaThyrocare Technologies Limited, IndiaBackground: Conventional serum markers are routinely recommended to assess heart health. However, many new biochemical markers like lipoprotein-associated phospholipase A2 (Lp-PLA2) has been studied as an efficient cardiac risk marker. Our report is an attempt to present correlation between traditional lipid markers and Lp-PLA2 in a pan-India cohort. Materials and Methods: The study cohort included a total of 10347 pan-Indians including 5945 males and 4402 females respectively. The serum lipid parameters estimated include triglycerides, LDL- and HDL-cholesterol as well as total cholesterol by the technology of photometry. Results: The frequency of high Lp-PLA2 detected in our study was 6.4% and the frequency between males at 9.3% and females at 2.5% was detected to be significant at p<0.0001. Linear regression analysis detected significant positive association of high Lp-PLA2 with LDL-cholesterol and total cholesterol at p<0.05, while the trend with HDL-cholesterol was also significant. However, Lp-PLA2 as an independent marker was not detected to be significant in relation to the lipid indices studied. Conclusion: Though Lp-PLA2 has been associated with risk factor for acute coronary crisis, its clinical value remains controversial. Our report though detected significant association of Lp-PLA2 with various lipid parameters, independent value remains questionable.https://www.nepjol.info/index.php/AJMS/article/view/22791lipoprotein phospholipase a2cardiac riskcholesterolindialdltriglycerides |
| spellingShingle | Sandhya Iyer Rajkumar Kushawaha Prachi Sinkar Sivakumar Selvaraj Amruta Velumani Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study Asian Journal of Medical Sciences lipoprotein phospholipase a2 cardiac risk cholesterol india ldl triglycerides |
| title | Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study |
| title_full | Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study |
| title_fullStr | Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study |
| title_full_unstemmed | Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study |
| title_short | Lipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study |
| title_sort | lipoprotein associated phospholipase a2 in relation to lipid markers a pan india correlation study |
| topic | lipoprotein phospholipase a2 cardiac risk cholesterol india ldl triglycerides |
| url | https://www.nepjol.info/index.php/AJMS/article/view/22791 |
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