Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and an established risk factor for cardiovascular diseases, including hypertension. The pathogenesis of elevated blood pressure (BP) in OSA is multifactorial, including sympathetic overdrive, vascular aberrations, oxidative stress, i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/4/866 |
| _version_ | 1797606667965169664 |
|---|---|
| author | Sanah S. Munir Fatima H. Sert Kuniyoshi Prachi Singh Naima Covassin |
| author_facet | Sanah S. Munir Fatima H. Sert Kuniyoshi Prachi Singh Naima Covassin |
| author_sort | Sanah S. Munir |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and an established risk factor for cardiovascular diseases, including hypertension. The pathogenesis of elevated blood pressure (BP) in OSA is multifactorial, including sympathetic overdrive, vascular aberrations, oxidative stress, inflammation, and metabolic dysregulation. Among the mechanisms potentially involved in OSA-induced hypertension, the role of the gut microbiome is gaining increasing attention. Perturbations in the diversity, composition, and function of the gut microbiota have been causally linked to numerous disorders, and robust evidence has identified gut dysbiosis as a determinant of BP elevation in various populations. In this brief review, we summarize the current body of literature on the implications of altered gut microbiota for hypertension risk in OSA. Data from both preclinical models of OSA and patient populations are presented, and potential mechanistic pathways are highlighted, along with therapeutic considerations. Available evidence suggests that gut dysbiosis may promote the development of hypertension in OSA and may thus be a target for interventions aimed at attenuating the adverse consequences of OSA in relation to cardiovascular risk. |
| first_indexed | 2024-03-11T05:18:23Z |
| format | Article |
| id | doaj.art-d9ca1cc26d1c44939cdc0a622e8f9699 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T05:18:23Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-d9ca1cc26d1c44939cdc0a622e8f96992023-11-17T18:05:27ZengMDPI AGAntioxidants2076-39212023-04-0112486610.3390/antiox12040866Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary ReviewSanah S. Munir0Fatima H. Sert Kuniyoshi1Prachi Singh2Naima Covassin3Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USADepartment of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USADepartment of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USAObstructive sleep apnea (OSA) is a highly prevalent sleep disorder and an established risk factor for cardiovascular diseases, including hypertension. The pathogenesis of elevated blood pressure (BP) in OSA is multifactorial, including sympathetic overdrive, vascular aberrations, oxidative stress, inflammation, and metabolic dysregulation. Among the mechanisms potentially involved in OSA-induced hypertension, the role of the gut microbiome is gaining increasing attention. Perturbations in the diversity, composition, and function of the gut microbiota have been causally linked to numerous disorders, and robust evidence has identified gut dysbiosis as a determinant of BP elevation in various populations. In this brief review, we summarize the current body of literature on the implications of altered gut microbiota for hypertension risk in OSA. Data from both preclinical models of OSA and patient populations are presented, and potential mechanistic pathways are highlighted, along with therapeutic considerations. Available evidence suggests that gut dysbiosis may promote the development of hypertension in OSA and may thus be a target for interventions aimed at attenuating the adverse consequences of OSA in relation to cardiovascular risk.https://www.mdpi.com/2076-3921/12/4/866cardiovascular diseasegut dysbiosisgut microbiomehypertensionhypoxiaobstructive sleep apnea |
| spellingShingle | Sanah S. Munir Fatima H. Sert Kuniyoshi Prachi Singh Naima Covassin Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review Antioxidants cardiovascular disease gut dysbiosis gut microbiome hypertension hypoxia obstructive sleep apnea |
| title | Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review |
| title_full | Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review |
| title_fullStr | Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review |
| title_full_unstemmed | Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review |
| title_short | Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review |
| title_sort | is the gut microbiome implicated in the excess risk of hypertension associated with obstructive sleep apnea a contemporary review |
| topic | cardiovascular disease gut dysbiosis gut microbiome hypertension hypoxia obstructive sleep apnea |
| url | https://www.mdpi.com/2076-3921/12/4/866 |
| work_keys_str_mv | AT sanahsmunir isthegutmicrobiomeimplicatedintheexcessriskofhypertensionassociatedwithobstructivesleepapneaacontemporaryreview AT fatimahsertkuniyoshi isthegutmicrobiomeimplicatedintheexcessriskofhypertensionassociatedwithobstructivesleepapneaacontemporaryreview AT prachisingh isthegutmicrobiomeimplicatedintheexcessriskofhypertensionassociatedwithobstructivesleepapneaacontemporaryreview AT naimacovassin isthegutmicrobiomeimplicatedintheexcessriskofhypertensionassociatedwithobstructivesleepapneaacontemporaryreview |