Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure
Abstract Aims The combination of haemoglobin, albumin, lymphocytes, and platelets (HALP) is a new metric used to assess patient prognosis in many diseases. This study aimed to assess the relationship between HALP and short‐ and long‐term mortality in patients with heart failure. Methods and results...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.14662 |
| _version_ | 1797242850446934016 |
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| author | Ling Liu Benbingdi Gong Wei Wang Kai Xu Kaoshan Wang Guixian Song |
| author_facet | Ling Liu Benbingdi Gong Wei Wang Kai Xu Kaoshan Wang Guixian Song |
| author_sort | Ling Liu |
| collection | DOAJ |
| description | Abstract Aims The combination of haemoglobin, albumin, lymphocytes, and platelets (HALP) is a new metric used to assess patient prognosis in many diseases. This study aimed to assess the relationship between HALP and short‐ and long‐term mortality in patients with heart failure. Methods and results This retrospective cohort study included adult patients with heart failure who were hospitalized between 2019 and 2021. The primary outcomes were 1‐month mortality and 1‐year mortality. The multivariable logistic regression analysis was used to evaluate the association between HALP and the risk of mortality. Stratified analyses were conducted based on New York Heart Association functional classification (NYHA) stage (II/III, IV) and left ventricular ejection fraction (LVEF, <50%, ≥50%). The area under the receiver operating characteristic curve (AUC) was used to evaluate the ability of HALP, prognostic nutritional index (PNI), C‐reactive protein (CRP), and the Meta‐Analysis Global Group in Chronic Heart Failure (MAGGIC‐HF) risk score in predicting mortality in patients with heart failure. A total of 730 patients with heart failure were included, of whom 61 (8.36%) died within 1 month and 77 (10.55%) died within 1 year. High HALP scores were associated with a reduced risk of 1‐month mortality (odds ratio (OR) = 0.978, 95% confidence interval (CI): 0.963–0.992, P = 0.003) and 1‐year mortality (OR = 0.987, 95% CI: 0.977–0.997, P = 0.009) in patients with heart failure. In patients with different NYHA stages or LVEF levels, high HALP scores were correlated with a reduced risk of 1‐year mortality in patients with NYHA stage II/III (OR = 0.978, 95% CI: 0.957–1.000, P = 0.045) or LVEF ≥50% (OR = 0.970, 95% CI: 0.945–0.996, P = 0.024). The AUC for HALP, PNI, CRP, and MAGGIC‐HF to predict 1‐year mortality in patients with heart failure were 0.677 (95% CI: 0.619–0.735), 0.666 (95% CI: 0.608–0.723), 0.638 (95% CI: 0.572–0.704), and 0.654 (95% CI: 0.591–0.717), respectively. Conclusions HALP may be a potential marker for predicting mortality in patients with heart failure. Further exploration based on HALP may yield better clinical predictors of prognosis in patients with heart failure. |
| first_indexed | 2024-04-24T18:45:46Z |
| format | Article |
| id | doaj.art-d9ca7edb8b3e4fa8ba78d0bf60b1ec6e |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-24T18:45:46Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-d9ca7edb8b3e4fa8ba78d0bf60b1ec6e2024-03-27T06:48:04ZengWileyESC Heart Failure2055-58222024-04-011121051106010.1002/ehf2.14662Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failureLing Liu0Benbingdi Gong1Wei Wang2Kai Xu3Kaoshan Wang4Guixian Song5Department of Cardiology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou ChinaDepartment of Cardiology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou ChinaDepartment of Cardiology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou ChinaDepartment of Cardiology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou ChinaDepartment of Cardiology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou ChinaDepartment of Cardiology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou ChinaAbstract Aims The combination of haemoglobin, albumin, lymphocytes, and platelets (HALP) is a new metric used to assess patient prognosis in many diseases. This study aimed to assess the relationship between HALP and short‐ and long‐term mortality in patients with heart failure. Methods and results This retrospective cohort study included adult patients with heart failure who were hospitalized between 2019 and 2021. The primary outcomes were 1‐month mortality and 1‐year mortality. The multivariable logistic regression analysis was used to evaluate the association between HALP and the risk of mortality. Stratified analyses were conducted based on New York Heart Association functional classification (NYHA) stage (II/III, IV) and left ventricular ejection fraction (LVEF, <50%, ≥50%). The area under the receiver operating characteristic curve (AUC) was used to evaluate the ability of HALP, prognostic nutritional index (PNI), C‐reactive protein (CRP), and the Meta‐Analysis Global Group in Chronic Heart Failure (MAGGIC‐HF) risk score in predicting mortality in patients with heart failure. A total of 730 patients with heart failure were included, of whom 61 (8.36%) died within 1 month and 77 (10.55%) died within 1 year. High HALP scores were associated with a reduced risk of 1‐month mortality (odds ratio (OR) = 0.978, 95% confidence interval (CI): 0.963–0.992, P = 0.003) and 1‐year mortality (OR = 0.987, 95% CI: 0.977–0.997, P = 0.009) in patients with heart failure. In patients with different NYHA stages or LVEF levels, high HALP scores were correlated with a reduced risk of 1‐year mortality in patients with NYHA stage II/III (OR = 0.978, 95% CI: 0.957–1.000, P = 0.045) or LVEF ≥50% (OR = 0.970, 95% CI: 0.945–0.996, P = 0.024). The AUC for HALP, PNI, CRP, and MAGGIC‐HF to predict 1‐year mortality in patients with heart failure were 0.677 (95% CI: 0.619–0.735), 0.666 (95% CI: 0.608–0.723), 0.638 (95% CI: 0.572–0.704), and 0.654 (95% CI: 0.591–0.717), respectively. Conclusions HALP may be a potential marker for predicting mortality in patients with heart failure. Further exploration based on HALP may yield better clinical predictors of prognosis in patients with heart failure.https://doi.org/10.1002/ehf2.14662Haemoglobin, albumin, lymphocytes, and platelets (HALP)Heart failureInflammationMortalityNutrition |
| spellingShingle | Ling Liu Benbingdi Gong Wei Wang Kai Xu Kaoshan Wang Guixian Song Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure ESC Heart Failure Haemoglobin, albumin, lymphocytes, and platelets (HALP) Heart failure Inflammation Mortality Nutrition |
| title | Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure |
| title_full | Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure |
| title_fullStr | Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure |
| title_full_unstemmed | Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure |
| title_short | Association between haemoglobin, albumin, lymphocytes, and platelets and mortality in patients with heart failure |
| title_sort | association between haemoglobin albumin lymphocytes and platelets and mortality in patients with heart failure |
| topic | Haemoglobin, albumin, lymphocytes, and platelets (HALP) Heart failure Inflammation Mortality Nutrition |
| url | https://doi.org/10.1002/ehf2.14662 |
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