Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study
Abstract Introduction We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163...
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.12185 |
| _version_ | 1828085270596026368 |
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| author | Jackie M. Poos Lucy L. Russell Georgia Peakman Martina Bocchetta Caroline V. Greaves Lize C. Jiskoot Emma L. van derEnde Harro Seelaar Janne M. Papma Esther vanden Berg Yolande A.L. Pijnenburg Barbara Borroni Raquel Sanchez‐Valle Fermin Moreno Robert Laforce Caroline Graff Matthias Synofzik Daniela Galimberti James B. Rowe Mario Masellis Carmela Tartaglia Elizabeth Finger Rik Vandenberghe Alexandre deMedonça Fabrizio Tagliavini Chris R. Butler Isabel Santana Isabelle Le Ber Alex Gerhard Simon Ducharme Johannes Levin Adrian Danek Markus Otto Sandro Sorbi Florence Pasquier John C. vanSwieten Jonathan D. Rohrer the Genetic FTD Initiative, GENFI |
| author_facet | Jackie M. Poos Lucy L. Russell Georgia Peakman Martina Bocchetta Caroline V. Greaves Lize C. Jiskoot Emma L. van derEnde Harro Seelaar Janne M. Papma Esther vanden Berg Yolande A.L. Pijnenburg Barbara Borroni Raquel Sanchez‐Valle Fermin Moreno Robert Laforce Caroline Graff Matthias Synofzik Daniela Galimberti James B. Rowe Mario Masellis Carmela Tartaglia Elizabeth Finger Rik Vandenberghe Alexandre deMedonça Fabrizio Tagliavini Chris R. Butler Isabel Santana Isabelle Le Ber Alex Gerhard Simon Ducharme Johannes Levin Adrian Danek Markus Otto Sandro Sorbi Florence Pasquier John C. vanSwieten Jonathan D. Rohrer the Genetic FTD Initiative, GENFI |
| author_sort | Jackie M. Poos |
| collection | DOAJ |
| description | Abstract Introduction We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73 microtubule‐associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel‐based morphometry to investigate the underlying neural substrates of the FCSRT. Results All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion The FCSRT detects presymptomatic deficits in C9orf72‐ and MAPT‐associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD. |
| first_indexed | 2024-04-11T04:37:21Z |
| format | Article |
| id | doaj.art-d9cbd03cbefe49ce99844f38963c0317 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:37:21Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-d9cbd03cbefe49ce99844f38963c03172022-12-28T09:12:14ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12185Impairment of episodic memory in genetic frontotemporal dementia: A GENFI studyJackie M. Poos0Lucy L. Russell1Georgia Peakman2Martina Bocchetta3Caroline V. Greaves4Lize C. Jiskoot5Emma L. van derEnde6Harro Seelaar7Janne M. Papma8Esther vanden Berg9Yolande A.L. Pijnenburg10Barbara Borroni11Raquel Sanchez‐Valle12Fermin Moreno13Robert Laforce14Caroline Graff15Matthias Synofzik16Daniela Galimberti17James B. Rowe18Mario Masellis19Carmela Tartaglia20Elizabeth Finger21Rik Vandenberghe22Alexandre deMedonça23Fabrizio Tagliavini24Chris R. Butler25Isabel Santana26Isabelle Le Ber27Alex Gerhard28Simon Ducharme29Johannes Levin30Adrian Danek31Markus Otto32Sandro Sorbi33Florence Pasquier34John C. vanSwieten35Jonathan D. Rohrer36the Genetic FTD Initiative, GENFI37Department of Neurology Erasmus Medical Center Rotterdam the NetherlandsDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UKDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UKDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UKDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UKDepartment of Neurology Erasmus Medical Center Rotterdam the NetherlandsDepartment of Neurology Erasmus Medical Center Rotterdam the NetherlandsDepartment of Neurology Erasmus Medical Center Rotterdam the NetherlandsDepartment of Neurology Erasmus Medical Center Rotterdam the NetherlandsDepartment of Neurology Erasmus Medical Center Rotterdam the NetherlandsDepartment of Neurology Alzheimer Center Location VU University Medical Center Amsterdam Amsterdam the NetherlandsCentre for Neurodegenerative Disorders Department of Clinical and Experimental Sciences University of Brescia Brescia ItalyAlzheimer's Disease and Other Cognitive Disorders Unit Neurology Service Hospital Clínic Institut d'Investigacións Biomèdiques August Pi I Sunyer University of Barcelona Barcelona SpainCognitive Disorders Unit Department of Neurology Donostia University Hospital San Sebastian Gipuzkoa SpainClinique Interdisciplinaire de Mémoire Département des Sciences Neurologiques CHU de Québec Faculté de Médecine Université Laval Quebec CanadaCenter for Alzheimer Research, Division of Neurogeriatrics Department of Neurobiology, Care Sciences and Society Bioclinicum Karolinska Institutet Solna SwedenDepartment of Neurodegenerative Diseases Hertie‐Institute for Clinical Brain Research and Center of Neurology University of Tübingen Tübingen GermanyDepartment of Biomedical, Surgical and Dental Sciences University of Milan Milan ItalyDepartment of Clinical Neurosciences Cambridge University Hospitals NHS Trust Medical Research Council Cognition and Brain Sciences Unit University of Cambridge Cambridge UKSunnybrook Health Sciences Centre Sunnybrook Research Institute University of Toronto Toronto CanadaTanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto CanadaDepartment of Clinical Neurological Sciences University of Western Ontario London CanadaLaboratory for Cognitive Neurology Department of Neurosciences KU Leuven Leuven BelgiumLaboratory of Neurosciences Institute of Molecular Medicine Faculty of Medicine University of Lisbon Lisbon PortugalFondazione IRCCS Istituto Neurologico Carlo Besta Milan ItalyNuffield Department of Clinical Neurosciences Medical Sciences Division University of Oxford Oxford UKUniversity Hospital of Coimbra (HUC) Neurology Service Faculty of Medicine University of Coimbra Coimbra PortugalSorbonne Université Institut du Cerveau (ICM) INSERM U1127 CNRS UMR 7225 APHP Hôpital Pitié‐Salpêtrière Paris FranceDivision of Neuroscience and Experimental Psychology Wolfson Molecular Imaging Centre University of Manchester, Manchester UKDouglas Mental Health University Institute Department of Psychiatry McGill University Montreal CanadaNeurologische Klinik und Poliklinik Ludwig‐Maximilians‐Universität Munich GermanyNeurologische Klinik und Poliklinik Ludwig‐Maximilians‐Universität Munich GermanyDepartment of Neurology University of Ulm Ulm GermanyDepartment of Neurofarba University of Florence Firenze ItalyUniversity of Lille Lille FranceDepartment of Neurology Erasmus Medical Center Rotterdam the NetherlandsDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UKDepartment of Neurology Erasmus Medical Center Rotterdam the NetherlandsAbstract Introduction We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73 microtubule‐associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel‐based morphometry to investigate the underlying neural substrates of the FCSRT. Results All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion The FCSRT detects presymptomatic deficits in C9orf72‐ and MAPT‐associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.https://doi.org/10.1002/dad2.12185cognitionepisodic memoryexecutive functionfrontal lobefrontotemporal dementiagenetic disorders |
| spellingShingle | Jackie M. Poos Lucy L. Russell Georgia Peakman Martina Bocchetta Caroline V. Greaves Lize C. Jiskoot Emma L. van derEnde Harro Seelaar Janne M. Papma Esther vanden Berg Yolande A.L. Pijnenburg Barbara Borroni Raquel Sanchez‐Valle Fermin Moreno Robert Laforce Caroline Graff Matthias Synofzik Daniela Galimberti James B. Rowe Mario Masellis Carmela Tartaglia Elizabeth Finger Rik Vandenberghe Alexandre deMedonça Fabrizio Tagliavini Chris R. Butler Isabel Santana Isabelle Le Ber Alex Gerhard Simon Ducharme Johannes Levin Adrian Danek Markus Otto Sandro Sorbi Florence Pasquier John C. vanSwieten Jonathan D. Rohrer the Genetic FTD Initiative, GENFI Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring cognition episodic memory executive function frontal lobe frontotemporal dementia genetic disorders |
| title | Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study |
| title_full | Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study |
| title_fullStr | Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study |
| title_full_unstemmed | Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study |
| title_short | Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study |
| title_sort | impairment of episodic memory in genetic frontotemporal dementia a genfi study |
| topic | cognition episodic memory executive function frontal lobe frontotemporal dementia genetic disorders |
| url | https://doi.org/10.1002/dad2.12185 |
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