Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons
Macroautophagy (hereafter autophagy) and endocytic trafficking are key pathways in neuronal axons that regulate the composition and integrity of the axonal proteome. These pathways have similar trafficking itineraries; however, the extent of their cross-talk remains incompletely understood. Our rece...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Autophagy Reports |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/27694127.2023.2166322 |
| _version_ | 1797685735211401216 |
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| author | Vineet Vinay Kulkarni Sandra Maday |
| author_facet | Vineet Vinay Kulkarni Sandra Maday |
| author_sort | Vineet Vinay Kulkarni |
| collection | DOAJ |
| description | Macroautophagy (hereafter autophagy) and endocytic trafficking are key pathways in neuronal axons that regulate the composition and integrity of the axonal proteome. These pathways have similar trafficking itineraries; however, the extent of their cross-talk remains incompletely understood. Our recent work demonstrates that under physiological conditions, axonal autophagy and endocytic pathways are separate and exhibit distinct rates of organelle maturation. Strikingly, overexpression of pathogenic α-synuclein disrupts the segregation between these pathways by merging autophagosomes and endosomes generated in the distal axon. These results raise the possibility that precocious degradation of endocytosed cargo via misrouting into lysosome-destined autophagosomes may contribute to neuronal dysfunction in Parkinson disease and related α-synucleinopathies. |
| first_indexed | 2024-03-12T00:55:38Z |
| format | Article |
| id | doaj.art-d9ccaa5c36b2420f8936df9684a42599 |
| institution | Directory Open Access Journal |
| issn | 2769-4127 |
| language | English |
| last_indexed | 2024-03-12T00:55:38Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj.art-d9ccaa5c36b2420f8936df9684a425992023-09-14T13:24:40ZengTaylor & Francis GroupAutophagy Reports2769-41272023-12-012110.1080/27694127.2023.21663222166322Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axonsVineet Vinay Kulkarni0Sandra Maday1Perelman School of Medicine at the University of PennsylvaniaPerelman School of Medicine at the University of PennsylvaniaMacroautophagy (hereafter autophagy) and endocytic trafficking are key pathways in neuronal axons that regulate the composition and integrity of the axonal proteome. These pathways have similar trafficking itineraries; however, the extent of their cross-talk remains incompletely understood. Our recent work demonstrates that under physiological conditions, axonal autophagy and endocytic pathways are separate and exhibit distinct rates of organelle maturation. Strikingly, overexpression of pathogenic α-synuclein disrupts the segregation between these pathways by merging autophagosomes and endosomes generated in the distal axon. These results raise the possibility that precocious degradation of endocytosed cargo via misrouting into lysosome-destined autophagosomes may contribute to neuronal dysfunction in Parkinson disease and related α-synucleinopathies.http://dx.doi.org/10.1080/27694127.2023.2166322α-synucleinautophagosomeaxonendosomelysosomeneuron |
| spellingShingle | Vineet Vinay Kulkarni Sandra Maday Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons Autophagy Reports α-synuclein autophagosome axon endosome lysosome neuron |
| title | Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons |
| title_full | Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons |
| title_fullStr | Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons |
| title_full_unstemmed | Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons |
| title_short | Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons |
| title_sort | sorting trash from treasure separate pathways for autophagy and endocytic trafficking in axons |
| topic | α-synuclein autophagosome axon endosome lysosome neuron |
| url | http://dx.doi.org/10.1080/27694127.2023.2166322 |
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