Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis

Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis

Summary: ZBP1 senses viral Z-RNAs to induce necroptotic cell death to restrain viral infection. ZBP1 is also thought to recognize host cell-derived Z-RNAs to regulate organ development and tissue inflammation in mice. However, it remains unknown how the host-derived Z-RNAs are formed and how these e...

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Bibliographic Details
Main Authors: Tao Yang, Guodong Wang, Mingxiang Zhang, Xiaohu Hu, Qi Li, Fenglin Yun, Yingying Xing, Xinyang Song, Haibing Zhang, Guohong Hu, Youcun Qian
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472301389X

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