Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes
The synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/19/4540 |
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| author | Joan J. Soldevila-Barreda Kehinde B. Fawibe Maria Azmanova Laia Rafols Anaïs Pitto-Barry Uche B. Eke Nicolas P. E. Barry |
| author_facet | Joan J. Soldevila-Barreda Kehinde B. Fawibe Maria Azmanova Laia Rafols Anaïs Pitto-Barry Uche B. Eke Nicolas P. E. Barry |
| author_sort | Joan J. Soldevila-Barreda |
| collection | DOAJ |
| description | The synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation of NADH and able to reduce NAD<sup>+</sup> with high turnover frequencies, in cells and in the presence of sodium formate, these complexes also strongly interact with biomolecules such as glutathione. This work highlights that efficient out-of-cells catalytic activity might lead to higher reactivity towards biomolecules, thus inhibiting the in-cells catalytic processes. |
| first_indexed | 2024-03-10T15:52:11Z |
| format | Article |
| id | doaj.art-d9cf533f4c974afb86a744ba4baab853 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:52:11Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d9cf533f4c974afb86a744ba4baab8532023-11-20T15:59:40ZengMDPI AGMolecules1420-30492020-10-012519454010.3390/molecules25194540Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich ComplexesJoan J. Soldevila-Barreda0Kehinde B. Fawibe1Maria Azmanova2Laia Rafols3Anaïs Pitto-Barry4Uche B. Eke5Nicolas P. E. Barry6School of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UKDepartment of Chemistry, University of Ilorin, Ilorin P.M.B 1515, NigeriaSchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UKSchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UKSchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UKDepartment of Chemistry, University of Ilorin, Ilorin P.M.B 1515, NigeriaSchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UKThe synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation of NADH and able to reduce NAD<sup>+</sup> with high turnover frequencies, in cells and in the presence of sodium formate, these complexes also strongly interact with biomolecules such as glutathione. This work highlights that efficient out-of-cells catalytic activity might lead to higher reactivity towards biomolecules, thus inhibiting the in-cells catalytic processes.https://www.mdpi.com/1420-3049/25/19/4540Indolehalf-sandwich complexesbioinorganic chemistrycatalytic drugsanticancer |
| spellingShingle | Joan J. Soldevila-Barreda Kehinde B. Fawibe Maria Azmanova Laia Rafols Anaïs Pitto-Barry Uche B. Eke Nicolas P. E. Barry Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes Molecules Indole half-sandwich complexes bioinorganic chemistry catalytic drugs anticancer |
| title | Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes |
| title_full | Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes |
| title_fullStr | Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes |
| title_full_unstemmed | Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes |
| title_short | Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes |
| title_sort | synthesis characterisation and in vitro anticancer activity of catalytically active indole based half sandwich complexes |
| topic | Indole half-sandwich complexes bioinorganic chemistry catalytic drugs anticancer |
| url | https://www.mdpi.com/1420-3049/25/19/4540 |
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