Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells

Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells

The fast and intense proliferative responses have been well documented for naïve T cells adoptively transferred into chronic lymphopenic hosts. This response known as spontaneous proliferation (SP), unlike antigen-independent lymphopenia-induced proliferation (LIP), is driven in a manner dependent o...

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Bibliographic Details
Main Authors: Juhee Kim, Jun Young Lee, Kyungjin Cho, Sung-Wook Hong, Kwang Soon Kim, Jonathan Sprent, Sin-Hyeog Im, Charles D. Surh, Jae-Ho Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
spontaneous proliferation
lymphopenia-induced homeostatic proliferation
naïve CD4 T+ cells
naïve CD8+ T cells
interleukin-2 (IL-2)
specific pathogen-free (SPF)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01907/full

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