Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review
Resveratrol is a polyphenolic phytoalexin, whose main natural sources are red grapes, red wine, berries, and peanuts. When applied to the skin, resveratrol evidences a good penetrating capacity and low degradation compared to the oral route, allowing for a longer and improved topical effect. This bi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/10/3/68 |
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| author | Filipa Mascarenhas-Melo André R. T. S. Araújo Márcio Rodrigues Ankita Mathur Maria Beatriz S. Gonçalves Kalpita Tanwar Fariba Heidarizadeh Fereshteh Nejaddehbashi Abbas Rahdar Priscila Gava Mazzola Francisco Veiga Ana Cláudia Paiva-Santos |
| author_facet | Filipa Mascarenhas-Melo André R. T. S. Araújo Márcio Rodrigues Ankita Mathur Maria Beatriz S. Gonçalves Kalpita Tanwar Fariba Heidarizadeh Fereshteh Nejaddehbashi Abbas Rahdar Priscila Gava Mazzola Francisco Veiga Ana Cláudia Paiva-Santos |
| author_sort | Filipa Mascarenhas-Melo |
| collection | DOAJ |
| description | Resveratrol is a polyphenolic phytoalexin, whose main natural sources are red grapes, red wine, berries, and peanuts. When applied to the skin, resveratrol evidences a good penetrating capacity and low degradation compared to the oral route, allowing for a longer and improved topical effect. This bioactive molecule has been gaining interest in dermo-pharmacy and cosmetics for the prevention and treatment of skin alterations. Its inherent meritorious biomedical potentials, including anti-aging, photoprotective, estrogen-like, skin-whitening, anti-acne, wound healing, anti-scarring, antimicrobial, and anti-skin cancer properties are the most evident. However, resveratrol evidences stability hurdles, becoming an unstable molecule when exposed to ultraviolet radiation. Several technological strategies have been developed to improve its stability, efficacy, and safety. We have described the main topical properties of resveratrol, and the involved mechanisms of action, and a great focus was placed on the technological strategies for the efficient application of resveratrol in dermatological and cosmetic formulations, including nanotechnology. |
| first_indexed | 2024-03-11T02:36:13Z |
| format | Article |
| id | doaj.art-d9cfd80bb59d4ce8a85b4d67917aa46e |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-11T02:36:13Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-d9cfd80bb59d4ce8a85b4d67917aa46e2023-11-18T09:54:53ZengMDPI AGCosmetics2079-92842023-04-011036810.3390/cosmetics10030068Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated ReviewFilipa Mascarenhas-Melo0André R. T. S. Araújo1Márcio Rodrigues2Ankita Mathur3Maria Beatriz S. Gonçalves4Kalpita Tanwar5Fariba Heidarizadeh6Fereshteh Nejaddehbashi7Abbas Rahdar8Priscila Gava Mazzola9Francisco Veiga10Ana Cláudia Paiva-Santos11Laboratory of Development and Drug Technologies, Faculty of Pharmacy, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, PortugalCPIRN-UDI-IPG—Center for Potential and Innovation of Natural Resources, Research Unit for Inland Development, Polytechnic Institute of Guarda, Av. Dr. Francisco de Sá Carneiro, 6300-559 Guarda, PortugalCPIRN-UDI-IPG—Center for Potential and Innovation of Natural Resources, Research Unit for Inland Development, Polytechnic Institute of Guarda, Av. Dr. Francisco de Sá Carneiro, 6300-559 Guarda, PortugalResearch and Development Department, Abode Biotech India Pvt. Limited, MLA Colony, Banjara Hills Hyderabad-Telangana, Hyderabad 500033, Telangana, IndiaLaboratory of Development and Drug Technologies, Faculty of Pharmacy, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, PortugalDepartment of Bioinformatics, Martin Luther Christian University, Dongktieh, Block-1, Nongrah, Shillong 793006, Meghalaya, IndiaDepartment of Chemistry, Shahid Chamran University of Ahvaz, Ahvaz 6135743169, IranCellular and Molecular Research Center, Medical Basic Sciences Institute, Ahvaz Jondishapur University of Medical Sciences, Ahvaz 61357-1579, IranDepartment of Physics, University of Zabol, Zabol 98613-35856, IranFaculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, SP, BrazilLaboratory of Development and Drug Technologies, Faculty of Pharmacy, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, PortugalLaboratory of Development and Drug Technologies, Faculty of Pharmacy, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, PortugalResveratrol is a polyphenolic phytoalexin, whose main natural sources are red grapes, red wine, berries, and peanuts. When applied to the skin, resveratrol evidences a good penetrating capacity and low degradation compared to the oral route, allowing for a longer and improved topical effect. This bioactive molecule has been gaining interest in dermo-pharmacy and cosmetics for the prevention and treatment of skin alterations. Its inherent meritorious biomedical potentials, including anti-aging, photoprotective, estrogen-like, skin-whitening, anti-acne, wound healing, anti-scarring, antimicrobial, and anti-skin cancer properties are the most evident. However, resveratrol evidences stability hurdles, becoming an unstable molecule when exposed to ultraviolet radiation. Several technological strategies have been developed to improve its stability, efficacy, and safety. We have described the main topical properties of resveratrol, and the involved mechanisms of action, and a great focus was placed on the technological strategies for the efficient application of resveratrol in dermatological and cosmetic formulations, including nanotechnology.https://www.mdpi.com/2079-9284/10/3/68resveratrolskintopicalnanotechnologybioactivity |
| spellingShingle | Filipa Mascarenhas-Melo André R. T. S. Araújo Márcio Rodrigues Ankita Mathur Maria Beatriz S. Gonçalves Kalpita Tanwar Fariba Heidarizadeh Fereshteh Nejaddehbashi Abbas Rahdar Priscila Gava Mazzola Francisco Veiga Ana Cláudia Paiva-Santos Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review Cosmetics resveratrol skin topical nanotechnology bioactivity |
| title | Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review |
| title_full | Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review |
| title_fullStr | Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review |
| title_full_unstemmed | Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review |
| title_short | Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy—An Updated Review |
| title_sort | dermatological bioactivities of resveratrol and nanotechnology strategies to boost its efficacy an updated review |
| topic | resveratrol skin topical nanotechnology bioactivity |
| url | https://www.mdpi.com/2079-9284/10/3/68 |
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