Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and Measurements
BackgroundTranscranial direct current stimulation (tDCS) modulates neural networks. Computer simulations, while used to identify how currents behave within tissues of different conductivity properties, still need to be complemented by physical models.Objective/HypothesisTo better understand tDCS eff...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00388/full |
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| author | Leon Morales-Quezada Mirret M. El-Hagrassy Beatriz Costa R. Andy McKinley Pengcheng Lv Felipe Fregni |
| author_facet | Leon Morales-Quezada Mirret M. El-Hagrassy Beatriz Costa R. Andy McKinley Pengcheng Lv Felipe Fregni |
| author_sort | Leon Morales-Quezada |
| collection | DOAJ |
| description | BackgroundTranscranial direct current stimulation (tDCS) modulates neural networks. Computer simulations, while used to identify how currents behave within tissues of different conductivity properties, still need to be complemented by physical models.Objective/HypothesisTo better understand tDCS effects on biology-mimicking tissues by developing and testing the feasibility of a high-fidelity 3D head phantom model that has sensing capabilities at different compartmental levels.MethodsModels obtained from MRI images generated 3D printed molds. Agar phantoms were fabricated, and 18 monitoring electrodes were placed on specific phantom brain areas.ResultsWhen using rectangular electrodes, the measured and simulated voltages at the monitoring electrodes agreed reasonably well, except at excitation locations. The electric field distribution in different phantom layers appeared better confined with circular electrodes compared to rectangular electrodes.ConclusionThe high-fidelity 3D head model was found to be feasible and comparable with computer-based electrical simulations, with high correlation between simulated and measured brain voltages. This feasibility study supports testing to further assess the reliability of this model. |
| first_indexed | 2024-12-20T02:45:08Z |
| format | Article |
| id | doaj.art-d9d1769b71df450c860d402d46a2eec3 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-20T02:45:08Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-d9d1769b71df450c860d402d46a2eec32022-12-21T19:56:12ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-10-011310.3389/fnhum.2019.00388490943Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and MeasurementsLeon Morales-Quezada0Mirret M. El-Hagrassy1Beatriz Costa2R. Andy McKinley3Pengcheng Lv4Felipe Fregni5Department of Physical Medicine and Rehabilitation, Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Physical Medicine and Rehabilitation, Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Physical Medicine and Rehabilitation, Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United StatesAir Force Research Laboratory, United States Air Force, Wright-Patterson AFB, Dayton, OH, United StatesAlphasense, Wilmington, DE, United StatesDepartment of Physical Medicine and Rehabilitation, Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United StatesBackgroundTranscranial direct current stimulation (tDCS) modulates neural networks. Computer simulations, while used to identify how currents behave within tissues of different conductivity properties, still need to be complemented by physical models.Objective/HypothesisTo better understand tDCS effects on biology-mimicking tissues by developing and testing the feasibility of a high-fidelity 3D head phantom model that has sensing capabilities at different compartmental levels.MethodsModels obtained from MRI images generated 3D printed molds. Agar phantoms were fabricated, and 18 monitoring electrodes were placed on specific phantom brain areas.ResultsWhen using rectangular electrodes, the measured and simulated voltages at the monitoring electrodes agreed reasonably well, except at excitation locations. The electric field distribution in different phantom layers appeared better confined with circular electrodes compared to rectangular electrodes.ConclusionThe high-fidelity 3D head model was found to be feasible and comparable with computer-based electrical simulations, with high correlation between simulated and measured brain voltages. This feasibility study supports testing to further assess the reliability of this model.https://www.frontiersin.org/article/10.3389/fnhum.2019.00388/fulltranscranial direct current simulationelectric stimulationelectric conductivitycomputer simulationsanatomic modelsEEG |
| spellingShingle | Leon Morales-Quezada Mirret M. El-Hagrassy Beatriz Costa R. Andy McKinley Pengcheng Lv Felipe Fregni Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and Measurements Frontiers in Human Neuroscience transcranial direct current simulation electric stimulation electric conductivity computer simulations anatomic models EEG |
| title | Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and Measurements |
| title_full | Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and Measurements |
| title_fullStr | Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and Measurements |
| title_full_unstemmed | Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and Measurements |
| title_short | Transcranial Direct Current Stimulation Optimization – From Physics-Based Computer Simulations to High-Fidelity Head Phantom Fabrication and Measurements |
| title_sort | transcranial direct current stimulation optimization from physics based computer simulations to high fidelity head phantom fabrication and measurements |
| topic | transcranial direct current simulation electric stimulation electric conductivity computer simulations anatomic models EEG |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00388/full |
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