Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics

Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics

Cytoskeleton organization and dynamics are rapidly regulated by post-translational modifications of key target proteins. Acting downstream of the Cdc42 GTPase, the myotonic dystrophy-related Cdc42-binding kinases MRCKα, MRCKβ, and MRCKγ have recently emerged as important players in cytoskeleton regu...

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Bibliographic Details
Main Authors: Vanessa M. Ruscetta, Taj J. Seaton, Aleen Shakeel, Stanley N. S. Vasconcelos, Russell D. Viirre, Marc J. Adler, Michael F. Olson
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
cytoskeleton
signal transduction
phosphorylation
Online Access:https://www.mdpi.com/2073-4409/12/4/534

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