The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration
The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of non-hematopoietic cells. This review focuses on recent report...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.02109/full |
| _version_ | 1818882451832832000 |
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| author | Marco E. Bianchi Marco E. Bianchi Rosanna Mezzapelle Rosanna Mezzapelle |
| author_facet | Marco E. Bianchi Marco E. Bianchi Rosanna Mezzapelle Rosanna Mezzapelle |
| author_sort | Marco E. Bianchi |
| collection | DOAJ |
| description | The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of non-hematopoietic cells. This review focuses on recent reports pointing to its pivotal role in tissue regeneration and stem cell activation, and discusses the connection to the known role of CXCR4 in promoting tumor growth. The mechanisms may be similar in all cases, since regeneration often recapitulates developmental processes, and cancer often exploits developmental pathways. Moreover, cell migration and cell proliferation appear to be downstream of the same signaling pathways. A deeper understanding of the complex signaling originating from CXCR4 is needed to exploit the opportunities to repair damaged organs safely and effectively. |
| first_indexed | 2024-12-19T15:17:58Z |
| format | Article |
| id | doaj.art-d9d40b68c6b44870aabb92db722e58bd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T15:17:58Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d9d40b68c6b44870aabb92db722e58bd2022-12-21T20:16:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.02109560971The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue RegenerationMarco E. Bianchi0Marco E. Bianchi1Rosanna Mezzapelle2Rosanna Mezzapelle3Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyDivision of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyThe CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of non-hematopoietic cells. This review focuses on recent reports pointing to its pivotal role in tissue regeneration and stem cell activation, and discusses the connection to the known role of CXCR4 in promoting tumor growth. The mechanisms may be similar in all cases, since regeneration often recapitulates developmental processes, and cancer often exploits developmental pathways. Moreover, cell migration and cell proliferation appear to be downstream of the same signaling pathways. A deeper understanding of the complex signaling originating from CXCR4 is needed to exploit the opportunities to repair damaged organs safely and effectively.https://www.frontiersin.org/article/10.3389/fimmu.2020.02109/fullchemokinecancertissue regenerationCXCL12HMGB1CXCR4 |
| spellingShingle | Marco E. Bianchi Marco E. Bianchi Rosanna Mezzapelle Rosanna Mezzapelle The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration Frontiers in Immunology chemokine cancer tissue regeneration CXCL12 HMGB1 CXCR4 |
| title | The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration |
| title_full | The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration |
| title_fullStr | The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration |
| title_full_unstemmed | The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration |
| title_short | The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration |
| title_sort | chemokine receptor cxcr4 in cell proliferation and tissue regeneration |
| topic | chemokine cancer tissue regeneration CXCL12 HMGB1 CXCR4 |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.02109/full |
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