The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration

The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration

The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of non-hematopoietic cells. This review focuses on recent report...

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Bibliographic Details
Main Authors: Marco E. Bianchi, Rosanna Mezzapelle
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
chemokine
cancer
tissue regeneration
CXCL12
HMGB1
CXCR4
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02109/full

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