Biomimetic Silica Microspheres in Biosensing
Lipid vesicles spontaneously fuse and assemble into a lipid bilayer on planar or spherical silica surfaces and other substrates. The supported lipid bilayers (SLBs) maintain characteristics of biological membranes, and are thus considered to be biomembrane mimetic systems that are stable because of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/15/3/1932/ |
| _version_ | 1828421016857083904 |
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| author | Reema Zeineldin Gabriel P. Lopez Sireesha Chemburu Kyle Fenton |
| author_facet | Reema Zeineldin Gabriel P. Lopez Sireesha Chemburu Kyle Fenton |
| author_sort | Reema Zeineldin |
| collection | DOAJ |
| description | Lipid vesicles spontaneously fuse and assemble into a lipid bilayer on planar or spherical silica surfaces and other substrates. The supported lipid bilayers (SLBs) maintain characteristics of biological membranes, and are thus considered to be biomembrane mimetic systems that are stable because of the underlying substrate. Examples of their shared characteristics with biomembranes include lateral fluidity, barrier formation to ions and molecules, and their ability to incorporate membrane proteins into them. Biomimetic silica microspheres consisting of SLBs on solid or porous silica microspheres have been utilized for different biosensing applications. The advantages of such biomimetic microspheres for biosensing include their increased surface area to volume ratio which improves the detection limits of analytes, and their amenability for miniaturization, multiplexing and high throughput screening. This review presents examples and formats of using such biomimetic solid or porous silica microspheres in biosensing. |
| first_indexed | 2024-12-10T15:21:50Z |
| format | Article |
| id | doaj.art-d9d4e30a9f0f4da6b6d9a894e951ca9f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T15:21:50Z |
| publishDate | 2010-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d9d4e30a9f0f4da6b6d9a894e951ca9f2022-12-22T01:43:39ZengMDPI AGMolecules1420-30492010-03-011531932195710.3390/molecules15031932Biomimetic Silica Microspheres in BiosensingReema ZeineldinGabriel P. LopezSireesha ChemburuKyle FentonLipid vesicles spontaneously fuse and assemble into a lipid bilayer on planar or spherical silica surfaces and other substrates. The supported lipid bilayers (SLBs) maintain characteristics of biological membranes, and are thus considered to be biomembrane mimetic systems that are stable because of the underlying substrate. Examples of their shared characteristics with biomembranes include lateral fluidity, barrier formation to ions and molecules, and their ability to incorporate membrane proteins into them. Biomimetic silica microspheres consisting of SLBs on solid or porous silica microspheres have been utilized for different biosensing applications. The advantages of such biomimetic microspheres for biosensing include their increased surface area to volume ratio which improves the detection limits of analytes, and their amenability for miniaturization, multiplexing and high throughput screening. This review presents examples and formats of using such biomimetic solid or porous silica microspheres in biosensing.http://www.mdpi.com/1420-3049/15/3/1932/biomimeticsilicamicrosphereporoussupported lipid bilayerfluorescenceflow cytometrymicrofluidicbiomembrane |
| spellingShingle | Reema Zeineldin Gabriel P. Lopez Sireesha Chemburu Kyle Fenton Biomimetic Silica Microspheres in Biosensing Molecules biomimetic silica microsphere porous supported lipid bilayer fluorescence flow cytometry microfluidic biomembrane |
| title | Biomimetic Silica Microspheres in Biosensing |
| title_full | Biomimetic Silica Microspheres in Biosensing |
| title_fullStr | Biomimetic Silica Microspheres in Biosensing |
| title_full_unstemmed | Biomimetic Silica Microspheres in Biosensing |
| title_short | Biomimetic Silica Microspheres in Biosensing |
| title_sort | biomimetic silica microspheres in biosensing |
| topic | biomimetic silica microsphere porous supported lipid bilayer fluorescence flow cytometry microfluidic biomembrane |
| url | http://www.mdpi.com/1420-3049/15/3/1932/ |
| work_keys_str_mv | AT reemazeineldin biomimeticsilicamicrospheresinbiosensing AT gabrielplopez biomimeticsilicamicrospheresinbiosensing AT sireeshachemburu biomimeticsilicamicrospheresinbiosensing AT kylefenton biomimeticsilicamicrospheresinbiosensing |