Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis
Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of mortality. The potential factors causing PF include viral infections, radiation exposure, and toxic airborne chemicals. Idiopathic PF (IPF) is related to pneumonia affecting the elderly and is characterized by r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/5/1481 |
| _version_ | 1797474467745628160 |
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| author | Mahbub Hasan Nidhan Chandra Paul Shamrat Kumar Paul Abu Saim Mohammad Saikat Hafeza Akter Manoj Mandal Sang-Suk Lee |
| author_facet | Mahbub Hasan Nidhan Chandra Paul Shamrat Kumar Paul Abu Saim Mohammad Saikat Hafeza Akter Manoj Mandal Sang-Suk Lee |
| author_sort | Mahbub Hasan |
| collection | DOAJ |
| description | Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of mortality. The potential factors causing PF include viral infections, radiation exposure, and toxic airborne chemicals. Idiopathic PF (IPF) is related to pneumonia affecting the elderly and is characterized by recurring scar formation in the lungs. An impaired wound healing process, defined by the dysregulated aggregation of extracellular matrix components, triggers fibrotic scar formation in the lungs. The potential pathogenesis includes oxidative stress, altered cell signaling, inflammation, etc. Nintedanib and pirfenidone have been approved with a conditional endorsement for the management of IPF. In addition, natural product-based treatment strategies have shown promising results in treating PF. In this study, we reviewed the recently published literature and discussed the potential uses of natural products, classified into three types—isolated active compounds, crude extracts of plants, and traditional medicine, consisting of mixtures of different plant products—in treating PF. These natural products are promising in the treatment of PF via inhibiting inflammation, oxidative stress, and endothelial mesenchymal transition, as well as affecting TGF-β-mediated cell signaling, etc. Based on the current review, we have revealed the signaling mechanisms of PF pathogenesis and the potential opportunities offered by natural product-based medicine in treating PF. |
| first_indexed | 2024-03-09T20:30:32Z |
| format | Article |
| id | doaj.art-d9d5882dc6bc40909de99e9dcc12e483 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T20:30:32Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d9d5882dc6bc40909de99e9dcc12e4832023-11-23T23:24:59ZengMDPI AGMolecules1420-30492022-02-01275148110.3390/molecules27051481Natural Product-Based Potential Therapeutic Interventions of Pulmonary FibrosisMahbub Hasan0Nidhan Chandra Paul1Shamrat Kumar Paul2Abu Saim Mohammad Saikat3Hafeza Akter4Manoj Mandal5Sang-Suk Lee6Department of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Dhaka 8100, BangladeshDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Dhaka 8100, BangladeshDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Dhaka 8100, BangladeshDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Dhaka 8100, BangladeshPharmacology and Toxicology Research Division, Health Medical Science Research Foundation, Dhaka 1207, BangladeshDepartment of Biochemistry and Molecular Biology, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Dhaka 8100, BangladeshDepartment of Oriental Biomedical Engineering, College of Health Sciences, Sangji University, Wonju 26339, KoreaPulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of mortality. The potential factors causing PF include viral infections, radiation exposure, and toxic airborne chemicals. Idiopathic PF (IPF) is related to pneumonia affecting the elderly and is characterized by recurring scar formation in the lungs. An impaired wound healing process, defined by the dysregulated aggregation of extracellular matrix components, triggers fibrotic scar formation in the lungs. The potential pathogenesis includes oxidative stress, altered cell signaling, inflammation, etc. Nintedanib and pirfenidone have been approved with a conditional endorsement for the management of IPF. In addition, natural product-based treatment strategies have shown promising results in treating PF. In this study, we reviewed the recently published literature and discussed the potential uses of natural products, classified into three types—isolated active compounds, crude extracts of plants, and traditional medicine, consisting of mixtures of different plant products—in treating PF. These natural products are promising in the treatment of PF via inhibiting inflammation, oxidative stress, and endothelial mesenchymal transition, as well as affecting TGF-β-mediated cell signaling, etc. Based on the current review, we have revealed the signaling mechanisms of PF pathogenesis and the potential opportunities offered by natural product-based medicine in treating PF.https://www.mdpi.com/1420-3049/27/5/1481pulmonary fibrosisnatural productstherapeutic targetsplant active compoundsplant extractsherbal medicine |
| spellingShingle | Mahbub Hasan Nidhan Chandra Paul Shamrat Kumar Paul Abu Saim Mohammad Saikat Hafeza Akter Manoj Mandal Sang-Suk Lee Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis Molecules pulmonary fibrosis natural products therapeutic targets plant active compounds plant extracts herbal medicine |
| title | Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis |
| title_full | Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis |
| title_fullStr | Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis |
| title_full_unstemmed | Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis |
| title_short | Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis |
| title_sort | natural product based potential therapeutic interventions of pulmonary fibrosis |
| topic | pulmonary fibrosis natural products therapeutic targets plant active compounds plant extracts herbal medicine |
| url | https://www.mdpi.com/1420-3049/27/5/1481 |
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