Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense

Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al. show that hemoglobin uptake in African trypanosomes is mediated almost exclusi...

Full description

Bibliographic Details
Main Authors:	Eva Horáková, Laurence Lecordier, Paula Cunha, Roman Sobotka, Piya Changmai, Catharina J. M. Langedijk, Jan Van Den Abbeele, Benoit Vanhollebeke, Julius Lukeš
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-022-34501-4

Similar Items

Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
by: Eva Horáková, et al.
Published: (2024-07-01)

Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria
by: Paschal Ugochukwu Umeakuana, et al.
Published: (2019-08-01)

The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense.
by: Paul Capewell, et al.
Published: (2013-01-01)

Trypanosoma brucei gambiense Infections in Mice Lead to Tropism to the Reproductive Organs, and Horizontal and Vertical Transmission.
by: Nicolas Biteau, et al.
Published: (2016-01-01)

The elimination of Trypanosoma brucei gambiense? Challenges of reservoir hosts and transmission cycles: Expect the unexpected
by: D. Mehlitz, et al.
Published: (2019-08-01)

Unexpected discovery of Trypanosoma brucei gambiense on CSF in a western country: About a case
by: Lou-Ann Francois, et al.
Published: (2024-07-01)

Domestic animals as potential reservoir hosts of Trypanosoma brucei gambiense in sleeping sickness foci in Cameroon
by: Njiokou F., et al.
Published: (2010-03-01)

Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense
by: Ammar Usman Danazumi, et al.
Published: (2022-01-01)

Seeing beyond 2020: an economic evaluation of contemporary and emerging strategies for elimination of Trypanosoma brucei gambiense
by: C Simone Sutherland, PhD, et al.
Published: (2017-01-01)

Midgut expression of immune-related genes in Glossina palpalis gambiensis challenged with Trypanosoma brucei gambiense
by: Illiassou eHamidou Soumana, et al.
Published: (2014-11-01)

Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T. b. gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa
by: Truc Philippe, et al.
Published: (2002-01-01)

Silent Human Trypanosoma brucei gambiense Infections around the Old Gboko Sleeping Sickness Focus in Nigeria
by: Karshima Solomon Ngutor, et al.
Published: (2016-01-01)

Trypanosoma brucei gambiense group 2 experimental in vivo life cycle: from procyclic to bloodstream form
by: Juban Paola, et al.
Published: (2024-01-01)

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1.
by: Paul Capewell, et al.
Published: (2011-09-01)

Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice.
by: Patient Pati Pyana, et al.
Published: (2011-01-01)

The effect of livestock density on Trypanosoma brucei gambiense and T. b. rhodesiense: A causal inference-based approach.
by: Julianne Meisner, et al.
Published: (2022-08-01)

Neural Damage in Experimental Trypanosoma brucei gambiense Infection: Hypothalamic Peptidergic Sleep and Wake-Regulatory Neurons
by: Claudia Laperchia, et al.
Published: (2018-02-01)

Correction: The miRNA and mRNA Signatures of Peripheral Blood Cells in Humans Infected with Trypanosoma brucei gambiense
Published: (2013-01-01)

Prospective evaluation of a rapid diagnostic test for Trypanosoma brucei gambiense infection developed using recombinant antigens.
by: Crispin Lumbala, et al.
Published: (2018-03-01)

Murine Models for Trypanosoma brucei gambiense disease progression--from silent to chronic infections and early brain tropism.
by: Christiane Giroud, et al.
Published: (2009-01-01)

Identification of mimotopes with diagnostic potential for Trypanosoma brucei gambiense variant surface glycoproteins using human antibody fractions.
by: Liesbeth Van Nieuwenhove, et al.
Published: (2012-01-01)

The origins of the trypanosome genome strains <it>Trypanosoma brucei brucei </it>TREU 927, <it>T. b. gambiense </it>DAL 972, <it>T. vivax </it>Y486 and <it>T. congolense </it>IL3000
by: Gibson Wendy
Published: (2012-04-01)

A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei.
by: Priscila Peña-Diaz, et al.
Published: (2017-04-01)

Hématologie de l’infection expérimentale à <em>Trypanosoma brucei gambiense</em> II. Changements érythrocytaires et leucocytaires
by: A.O. Emeribe, et al.
Published: (1991-01-01)

MIF contributes to Trypanosoma brucei associated immunopathogenicity development.
by: Benoît Stijlemans, et al.
Published: (2014-09-01)

Wild chimpanzees are infected by Trypanosoma brucei
by: Milan Jirků, et al.
Published: (2015-12-01)

The Dermis as a Delivery Site of Trypanosoma brucei for Tsetse Flies.
by: Guy Caljon, et al.
Published: (2016-07-01)

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates
by: Fabrice E. Graf, et al.
Published: (2015-08-01)

Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo.
by: Patient Pyana Pati, et al.
Published: (2014-10-01)

Expression of a variant surface glycoprotein of Trypanosoma gambiense in procyclic forms of Trypanosoma brucei shows that the cell type dictates the nature of the glycosylphosphatidylinositol membrane anchor attached to the glycoprotein
by: Paturiaux-Hanocq, F, et al.
Published: (1997)

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei.
by: Simon Urwyler, et al.
Published: (2005-11-01)

Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance.
by: Rebecca E Symula, et al.
Published: (2012-01-01)

Implications of Heterogeneous Biting Exposure and Animal Hosts on Trypanosomiasis brucei gambiense Transmission and Control.
by: Chris M Stone, et al.
Published: (2015-10-01)

Molecular Identification of Trypanosome Diversity in Domestic Animals Reveals the Presence of <i>Trypanosoma brucei gambiense</i> in Historical Foci of Human African Trypanosomiasis in Gabon
by: Larson Boundenga, et al.
Published: (2022-08-01)

Molecular identification of Trypanosoma brucei gambiense in naturally infected pigs, dogs and small ruminants confirms domestic animals as potential reservoirs for sleeping sickness in Chad
by: Vourchakbé Joël, et al.
Published: (2020-01-01)

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction
by: Hagen Sülzen, et al.
Published: (2023-04-01)

A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.
by: Géraldine De Muylder, et al.
Published: (2013-10-01)

T-tubulin in Trypanosoma brucei
by: Scott, V, et al.
Published: (1996)

SUMOylation in Trypanosoma brucei
by: Cornelia Andrea Klein, et al.
Published: (2013-10-01)

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes
by: S Andrea Moreno, et al.
Published: (2015-06-01)